血清胱抑素C、尿N-乙酰-β-D-葡萄糖苷酶检测在狼疮性肾炎诊断中的应用价值分析  

Application Value Analysis of Detection of Serum Cystatin C and Urinary N-Acetyl-β-D-Glucosaminidase in Diagnosis of Lupus Nephritis

作　　者：马玲飞 黄鹂 崔莉红 顾向前 马晓红 Ma Lingfei;Huang Li;Cui Lihong;Gu Xiangqian;Ma Xiaohong(Department of Medical Laboratory,Wuzhong People's Hospital,Wuzhong 751100,Ningxia Hui Autonomous Region,China)

机构地区：[1]吴忠市人民医院医学检验科,宁夏回族自治区吴忠751100

出　　处：《中国社区医师》2024年第30期95-97,共3页Chinese Community Doctors

摘　　要：目的:探讨血清胱抑素C(CysC)、尿N-乙酰-β-D-氨基葡萄糖苷酶(NAG)检测在狼疮性肾炎诊断中的应用价值。方法:选取2021年1月—2023年12月吴忠市人民医院收治的100例狼疮性肾炎患者作为观察组,选取同期健康体检者50例作为对照组,并将观察组根据肾脏损伤情况分为狼疮组(n=30)、早期肾炎组(n=30)、肾炎组(n=40)。观察组、对照组均接受血清Cys C、尿NAG检测。比较观察组、对照组及观察组3个亚组血清CysC、尿NAG水平,比较观察组3个亚组血清CysC、尿NAG阳性检出率。结果:观察组血清CysC、尿NAG水平均高于对照组,差异有统计学意义(P<0.05)。对照组与观察组3个亚组血清CysC、尿NAG水平对比,对照组<狼疮组<早期肾炎组<肾炎组,差异有统计学意义(P<0.05)。观察组3个亚组血清CysC、尿NAG阳性检出率对比,肾炎组>早期肾炎组>狼疮组,差异有统计学意义(P<0.05)。结论:血清CysC、尿NAG检测在狼疮性肾炎诊断中的应用价值较高,能够为疾病诊断和肾脏损伤程度的鉴别提供科学依据。Objective:To explore the application value of the detection of serum cystatin C(CysC)and urinary N-acetyl-β-Dglucosaminidase(NAG)in the diagnosis of lupus nephritis.Methods:A total of 100 patients with lupus nephritis admitted to Wuzhong People's Hospital from January 2021 to December 2023 were selected as the observation group,and 50 healthy subjects undergoing physical examination during the same period were selected as the control group.The observation group was divided into lupus group(n=30),early nephritis group(n=30)and nephritis group(n=40)according to kidney injury.Both the observation group and the control group were tested for serum CysC and urinary NAG.The serum CysC and urinary NAG levels in the observation group,the control group and three subgroups of the observation group were compared.The positive detection rates of serum CysC and urinary NAG were compared among the three subgroups of the observation group.Results:The serum CysC and urinary NAG levels in the observation group were higher than those in the control group,and the difference was statistically significant(P<0.05).The serum CysC and urinary NAG levels in the control group and three subgroups of the observation group were compared and ranked as follows:control group<lupus group<early nephritis group<nephritis group,and the difference was statistically significant(P<0.05).The positive detection rates of serum CysC and urinary NAG among the three subgroups of the observation group were compared and ranked as follows:nephritis group>early nephritis group>lupus group,and the difference was statistically significant(P<0.05).Conclusion:The detection of serum CysC and urinary NAG has a higher application value in the diagnosis of lupus nephritis,and can provide scientific basis for the disease diagnosis and the differentiation of kidney injury degree.

关 键 词：狼疮性肾炎 胱抑素C 尿N-乙酰-β-D-葡萄糖苷酶 

分 类 号：R593.242[医药卫生—内科学]