频繁发作慢性阻塞性肺疾病患者Treg/Th17变化及炎症细胞表型特征差异分析  

Treg/Th 17 changes and differences in inflammatory cell phenotypes in patients with frequent episodes of chronic obstructive pulmonary disease

作　　者：李强如 史振龙 赵军喜[1] Li Qiangru;Shi Zhenlong;Zhao Junxi(The Sixth Department of Internal Medicine,Anyang Second People's Hospital,Anyang,Henan 455000,China)

机构地区：[1]安阳市第二人民医院内六科,河南安阳455000

出　　处：《齐齐哈尔医学院学报》2024年第20期1936-1940,共5页Journal of Qiqihar Medical University

摘　　要：目的探讨频繁发作慢性阻塞性肺疾病(COPD)患者调节性T淋巴细胞(Treg)/T辅助性T细胞17(Th17)变化及炎症细胞表型特征差异。方法选择2021年11月—2024年2月本院收治的80例COPD患者作为研究对象,根据1年内急性加重发作次数将患者分为频繁加重(FE)组(34例)和非频繁发作(iFE)组(46例)两组。比较两组患者临床资料;比较两组患者Treg、Th17细胞百分比和Treg/Th17比值;pearson相关性分析COPD患者Treg、Th17细胞百分比与COPD急性加重频率的关系;比较两组患者炎症细胞表型比例。结果FE组FEV1和FEV1/FVC明显低于iFE组,急性加重频率明显高于iFE组(P<0.05);FE组COPD患者Treg细胞百分比和Treg/Th17比值均明显低于iFE组,Th17细胞百分比则明显高于iFE组(P<0.05);pearson相关性分析,COPD患者Treg细胞百分比和Treg/Th17比值与COPD急性加重频率呈正相关,Th17细胞百分比与COPD急性加重频率呈负相关(P<0.05);FE组COPD患者EC炎症细胞表型比例为44.12%,显著高于iFE组的19.57%(P<0.05)。结论频繁发作COPD患者普遍存在机体Treg和Th17平衡失衡,EC炎症细胞表型患者COPD频繁发作风险更高。Objective To explore the changes in regulatory T lymphocytes(Treg)/T helper 17(Th17)cells and the differences in inflammatory cell phenotype characteristics in patients with frequent episodes of chronic obstructive pulmonary disease(COPD).Methods Eighty COPD patients admitted to Anyang Second People's Hospital from November 2021 to February 2024 were enrolled as study subjects and divided into frequent exacerbation(FE)group(n=34)and infrequent exacerbation(iFE)group(n=46)based on the number of acute exacerbations within one year.The clinical data of COPD patients in the FE and iFE groups were compared,as well as the percentages of Treg and Th17 cells and the Treg/Th17 ratio.The relationship between the percentages of Treg and Th17 cells and the frequency of COPD exacerbation was analyzed by Pearson correlation.Additionally,the proportion of inflammatory cell phenotypes in COPD patients in the FE and iFE groups was compared.Results FEV1 and FEV1/FVC were significantly lower in the FE group than in the iFE group,while the frequency of acute exacerbations was significantly higher in the FE group than in the iFE group(P<0.05).The percentage of Treg cells and the Treg/Th17 ratio in COPD patients in the FE group were significantly lower than those in the iFE group,while the percentage of Th17 cells was significantly higher than that in the iFE group(P<0.05).Pearson correlation analysis showed that the percentage of Treg cells and the Treg/Th17 ratio were positively correlated with the frequency of acute exacerbation of COPD,and the percentage of Th17 cells was inversely associated with the frequency of acute COPD exacerbation(P<0.05).The proportion of EC inflammatory cell phenotype in COPD patients in the FE group was 44.12%,which was significantly higher than the 19.57%in the iFE group(P<0.05).Conclusions Imbalance of Treg and Th17 is common in patients with frequent COPD episodes,and patients with the EC inflammatory cell phenotype are at a higher risk of frequent COPD attacks.

关 键 词：慢性阻塞性肺疾病 频繁发作 调节性T淋巴细胞 T辅助性T细胞17 炎症细胞表型 

分 类 号：R563.9[医药卫生—呼吸系统]