CXC基序趋化因子配体1与心血管疾病的研究进展  

Research progress of CXC motif chemokine ligand 1 and cardiovascular diseases

作　　者：杨泾纬 谷云飞[1] YANG Jing-wei;GU Yun-fei(Department of Cardiology,Luoyang Central Hospital Affiliated to Zhengzhou University,Luoyang 471000,China)

机构地区：[1]郑州大学附属洛阳市中心医院心内科,河南省洛阳市471000

出　　处：《中国心血管病研究》2024年第11期973-977,共5页Chinese Journal of Cardiovascular Research

基　　金：河南省重点研发与推广项目(222102310076)。

摘　　要：心血管疾病是一类具有高残疾率和病死率的疾病。多项研究表明,心血管疾病与炎症、免疫、损伤和修复密切相关。CXC基序趋化因子配体1(CXCL1)是趋化因子超家族中的一员,具有调节炎症反应和促进血管重塑的作用。CXCL1参与心血管系统的纤维化过程,可诱发冠状动脉粥样硬化性心脏病、心力衰竭、心房颤动等心血管疾病。敲除CXCL1基因或使用CXC家族趋化因子受体2(CXCR2)受体抑制剂可以改善心功能和心脏重构。本文旨在探讨CXCL1与心血管疾病研究的最新进展作一综述。Cardiovascular diseases are a category of diseases with high disability and mortality rates.Numerous studies have shown that cardiovascular diseases are closely related to inflammation,immunity,injury,and repair.CXC motif chemokine ligand 1(CXCL1)is a member of the chemokine superfamily and plays a role in regulating inflammatory responses and promoting vascular remodeling.CXCL1 is involved in the fibrosis process of the cardiovascular system and can induce cardiovascular diseases such as coronary atherosclerotic heart disease,heart failure(HF)and atrial fibrillation(AF).Knocking out the CXCL1 gene or using a Chemokine Receptor 2 of the CXC family(CXCR2)receptor inhibitor can improve cardiac function and cardiac remodeling.This article aims to review the latest progress in the research on CXCL1 and cardiovascular diseases.

关 键 词：CXC基序趋化因子配体1 心血管疾病 炎症 纤维化 

分 类 号：R54[医药卫生—心血管疾病]