生物膜-硅胶喉模复合体在防治声带粘连中的临床应用分析  

Clinical analysis of biomaterial-silicone keel complex in the vocal folds adhesion treatment

作　　者：李旭茂 谢予晖 陈翔宇 崔西栋 孙广滨 LI Xumao;XIE Yuhui;CHEN Xiangyu;CUI Xidong;SUN Guangbin(Department of Otorhinolaryngology-Head and Neck Surgery,Huashan Hospital,Fudan University,Shanghai,200040,China)

机构地区：[1]复旦大学附属华山医院耳鼻咽喉头颈外科,上海200040

出　　处：《临床耳鼻咽喉头颈外科杂志》2024年第10期903-906,共4页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

基　　金：国家自然科学基金(No:82271154)。

摘　　要：目的:探讨生物膜联合喉模技术在声带粘连的预防和治疗中的临床效果。方法:回顾性分析复旦大学附属华山医院诊治的21例接受生物膜-硅胶喉模复合体技术防治声带粘连患者的基本资料、围手术期一般情况及治疗预后。结果:纳入21例患者中男19例(90.5%),女2例(9.5%),其中18例早期声门型喉癌(T1b)、1例双侧声带白斑及2例喉术后声带粘连患者。围术期均未发生喉模意外脱离,术后平均(22.4±2.6)d拆除硅胶模。术后定期复查,整体有效率为90.5%(19/21)。术后5例患者出现并发症(1例喉内感染、4例肉芽组织增生),经保守治疗后均痊愈。结论:本研究初步探索了生物膜材料在防治声带粘连中的可行性,该生物膜-硅胶喉模复合体技术操作简便,预防声带粘连效果良好,值得临床推广。Objective To retrospectively analyze the clinical effect of biomaterial combined with silicone keel technology in the prevention and treatment of vocal folds adhesion.Methods The basic data,perioperative conditions and prognosis of 21 cases of vocal folds adhesion treated by biofilm-silicone keel complex were retrospectively analyzed in Huashan Hospital Fudan University.Results A total of 21 patients were enrolled in this study 19 males(90.5%),2 females(9.5%).Among these patients,18 cases of early glottic laryngeal carcinoma(T1b),1 case of bilateral vocal folds leukoplecta and 2 cases of postoperative vocal folds adhesion.No accidental rupture of the silicone keel occurred during perioperative period,and the silicone keel was removed in 22.4±2.6 days.All patients were reviewed after removing the silicone keel,the overall effective rate was 90.5%(19/21).Postoperative complications occurred in 5 patients(1 laryngeal infection,4 granulation tissue hyperplasia),all of whom were cured after conservative treatment.Conclusion This study explored the feasibility of biomaterial in the treatment of vocal folds adhesion.The biomaterial-silicone keel complex technology is simple to operate and has effect on the prevention of vocal folds adhesions,which is worth of clinical promotion.

关 键 词：声带粘连 生物膜 喉模 治疗 

分 类 号：R767[医药卫生—耳鼻咽喉科]