记忆T细胞与变应性鼻炎发病机制的研究进展  

Research progress of memory T cells in the pathogenesis of allergic rhinitis

作　　者：高雅玟 龙波锦 余少卿[1] GAO Yawen;LONG Bojin;YU Shaoqing(Department of Otorhinolaryngology Head and Neck Surgery,Tongji Hospital,School of Medicine,Tongji University,Shanghai,200065,China)

机构地区：[1]同济大学附属同济医院耳鼻咽喉头颈外科,上海200065

出　　处：《临床耳鼻咽喉头颈外科杂志》2024年第10期975-978,共4页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

基　　金：科技部国家重点研发项目(No:2022YFC2504100);上海市综合医院中西医结合专项(No:ZHYY-ZXYJHZX-202118);市级医院新兴前沿联合攻关项目(No:SHDC12024126)

摘　　要：变应性鼻炎(AR)是特应性个体暴露于过敏原后主要由免疫球蛋白E(IgE)介导的鼻黏膜非感染性慢性炎性疾病,T细胞是其中的核心细胞群。近年来,研究表明记忆T细胞在AR发病的发生发展中发挥着重要作用。本文就记忆T细胞在AR中的发病机制进行综述,以期进一步完善AR的发病机制,为后续临床上药物治疗提供理论依据和参考。Objective Allergic rhinitis(AR)is a non-infectious chronic inflammatory disease of the nasal mucosa mainly mediated by immunoglobulin E(IgE)in atopic individuals after exposure to allergens.T cells are the core cell population.In recent years,studies have shown that memory T cells play an important role in the development of allergic rhinitis.This article reviews the pathogenesis of memory T cells in allergic rhinitis,in order to further improve the pathogenesis of allergic rhinitis and provide theoretical basis and reference for subsequent clinical drug treatment.

关 键 词：记忆T细胞 变应性鼻炎 发病机制 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]