基于功能连接密度评估青少年男性网络游戏障碍患者脑功能损伤机制  

Assessment of mechanisms of brain functional impairment in adolescent males with internet gaming disorder based on intra-and interhemispheric functional connectivity density

作　　者：马泷耀 张勇[1] 陶秋影 孙洁萍 党婧晗 汪卫建 程敬亮[1] MA Longyao;ZHANG Yong;TAO Qiuying;SUN Jieping;DANG Jinghan;WANG Weijian;CHENG Jingliang(Department of MRI,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450002,China)

机构地区：[1]郑州大学第一附属医院磁共振科,郑州450002

出　　处：《磁共振成像》2024年第10期69-73,79,共6页Chinese Journal of Magnetic Resonance Imaging

基　　金：河南省重点研发与推广专项(科技攻关)(编号:212102310712)。

摘　　要：目的为了评估网络游戏障碍脑功能损伤机制,本文应用基于半球内和半球间功能连接密度(functional connectivity density,FCD)的分析方法研究青少年男性网络游戏障碍患者脑区之间功能连接的异常改变。材料与方法对55名网络游戏障碍患者的静息状态功能磁共振图像和人口资料相匹配的50名健康对照者行全脑FCD的计算。再将全脑FCD分为同侧和对侧部分。采用双样本t检验比较网络游戏障碍组与健康对照组全脑、半球内和半球间FCD的差异。最后采用Pearson相关性分析探究网络游戏障碍患者全脑、半球内和半球间FCD值的变化与临床行为的相关性。结果网络游戏障碍组与健康对照组FCD的差异在全脑水平上主要分布于左侧楔前叶、左侧后扣带回与左侧颞中回。与健康对照组相比,网络游戏障碍患者在左侧楔前叶和左侧后扣带回中表现出半球间FCD的降低(t=-5.317、-3.556);此外,网络游戏障碍患者在左侧颞中回,左侧楔前叶与左侧后扣带回还表现出半球内FCD的降低(t=-5.044、-5.359、-4.183)(均体素水平P<0.005,团块水平P<0.05,高斯随机场校正)。结论网络游戏障碍患者在默认模式网络内存在半球内和半球间的功能连接异常。本研究将为网络游戏障碍患者的病理生理学机制和临床诊治提供新的见解。Objective:To assess the mechanism of brain functional impairment,the intra-and interhemispheric functional connectivity density(FCD)analysis was applied to investigate abnormal alterations in functional connectivity within brain regions in adolescent males with internet gaming disorder.Materials and Methods:Global FCD calculation on resting-state functional magnetic resonance images of 55 individuals with internet gaming disorder and demographically matched 50 healthy controls.The global FCD was then divided into ipsilateral and contralateral components.The global,intrahemisphere,and interhemispheric FCD between internet gaming disorder group and healthy control group were analyzed using a two-sample t-test.Finally,Pearson correlation analyses were performed between alternations of global,intrahemisphere,and interhemispheric FCD value in individuals with internet gaming disorder and clinical behavior.Results:The global FCD differences between the internet gaming disorder and the healthy control were mainly located in the left precuneus,the left posterior cingulate gyrus and the left middle temporal gyrus.Compared to healthy controls,individuals with internet gaming disorder showed decreased interhemispheric FCD in the left precuneus and left posterior cingulate gyrus(t=−5.317,−3.556).In addition,individuals with internet gaming disorder also demonstrated decreased intrahemispheric FCD in the left middle temporal gyrus,the left precuneus,and the left posterior cingulate gyrus(t=−5.044,−5.359,−4.183)(voxel level P<0.005,cluster level P<0.05,Gaussian random fields corrected).Conclusions:Functional intrahemispheric and interhemispheric connectivity abnormalities within default mode network regions are observed in individuals with internet gaming disorder.This study will provide new insights into the pathophysiologic mechanisms and clinical diagnosis and treatment of individuals with internet gaming disorder.

关 键 词：网络游戏障碍 磁共振成像 功能连接密度 偏侧化 静息状态功能磁共振成像 默认模式网络 

分 类 号：R445.2[医药卫生—影像医学与核医学] R749.1[医药卫生—诊断学]