基于大尺度脑网络对神经精神狼疮患者脑功能研究  

To study the brain function of patients with neuropsychiatric lupus based on the functional connectivity of large-scale brain networks

作　　者：马悦 马雪英 倪沙 安宁 杨超 乔鹏飞[2] MA Yue;MA Xueying;NI Sha;AN Ning;YANG Chao;QIAO Pengfei(The First Clinical Medical College,Inner Mongolia Medical University,Hohhot 010050,China;Department of Imaging Diagnosis,Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010050,China;Department of Medical Imaging,Inner Mongolia Aerospace Hospital,Hohhot 010050,China)

机构地区：[1]内蒙古医科大学第一临床医学院,呼和浩特010050 [2]内蒙古医科大学附属医院影像诊断科,呼和浩特010050 [3]内蒙古航天医院医学影像科,呼和浩特010050

出　　处：《磁共振成像》2024年第10期74-79,共6页Chinese Journal of Magnetic Resonance Imaging

基　　金：内蒙古医科大学联合项目(编号:YKD2021LH010)。

摘　　要：目的本研究旨在通过独立成分分析方法对神经精神狼疮(neuropsychiatric systemic lupus erythematosus,NPSLE)患者的脑功能进行分析,从影像学方面入手对NPSLE患者认知障碍的出现进行探讨。材料与方法纳入内蒙古医科大学附属医院风湿科住院部2021年9月至2023年12月NPSLE患者67例与同期招募的健康对照33例。采集静息态数据和结构像数据,基于MATLAB平台使用Dpabi软件包对数据进行预处理,并使用GIFT软件包分析两组受试者的数据,提取出30个独立成分,根据Yeo七网络模板严格匹配及有经验医师确认后选取独立成分构建8个网络,计算不同脑网络之间的功能连接,将不同脑网络之间的功能连接值与临床资料及认知评估行相关性分析。结果与健康对照相比:狼疮组左侧额顶网络与感觉运动网络、默认模式网络间的功能连接减低(P<0.05),默认模式网络与感觉运动网络、执行控制网络间的功能连接减低(P<0.05),左侧额顶网络与视觉网络间的功能连接升高(P<0.05),感觉运动网络与听觉网络、凸显网络及视觉网络间的功能连接升高(P<0.05)。相关性结果显示默认模式网络_感觉运动网络间的功能连接值与抗双链DNA抗体(抗ds DNA)呈负相关(P=0.028,r=-0.270),感觉运动网络_凸显网络间的功能连接值与听觉词语测试_前3次(AVL_前3次)得分呈负相关(P=0.006,r=-0.275),默认模式网络与执行控制网络间的功能连接值与红细胞比容呈正相关(P=0.043,r=0.250)、与AVL_前3次得分呈负相关(P=0.025,r=-0.224)。结论NPSLE患者不同脑网络之间的功能连接呈现程度不一的改变,且与狼疮自身抗体、血液学指标及神经心理测评呈现相关性,提示狼疮患者脑网络的改变可能与认知障碍的出现有关。Objective:To analyze the brain function of patients with neuropsychiatric systemic lupus erythematosus(NPSLE)using independent component analysis(ICA),investigating the appearance of cognitive impairment in NPSLE from the perspective of imaging.Materials and Methods:Tixty-seven patients with NPSLE admitted to the Rheumatology Department of the Affiliated Hospital of Inner Mongolia Medical University from September 2021 to December 2023 were included,along with 33 healthy controls(HC)recruited during the same period.Resting-state and structural data were collected,and the data were preprocessed using the Dpabi based on the MATLAB.The GIFT was used to analyze the data of both groups of subjects,extracting 30 independent components.After strict matching according to the Yeo 7 network template and confirmation by experienced doctors,8 networks were constructed by selecting independent components,and the work between different brain networks was calculated.The connectivity between different brain networks was calculated,and the functional connectivity(FC)values between different brain networks were correlated with clinical data and cognitive assessments.Results:Compared with HC,the FC between the left frontoparietal network(LFPN)and the sensorimotor network(SMN),the default network(DMN)was reduced in the NPSLE group(P<0.05),and the FC between DMN and SMN,executive control network(ECN)was also reduced(P<0.05).The FC between the LFPN and the visual network(VN)was increased(P<0.05),and the FC between the SMN and the auditory network(AN),salience network(SN),and VN was increased(P<0.05).The correlation results show that the FC between the DMN_SMN was negatively correlated with anti-ds DNA(P=0.028,r=−0.270),the FC between the SMN_SN was negatively correlated with AVL_first 3 times(P=0.006,r=−0.275),and the FC value between the DMN_ECN was positively correlated with hematocrit(P=0.043,r=0.250)and negatively correlated with AVL_first 3 times(P=0.025,r=−0.224).Conclusions:In NPSLE,there are varying degrees of changes in

关 键 词：神经精神狼疮 磁共振成像 脑网络 脑功能 认知障碍 独立成分分析 

分 类 号：R445.2[医药卫生—影像医学与核医学] R593.241[医药卫生—诊断学]