基于扩散张量成像对Rolandic癫痫儿童脑白质微观结构与认知障碍相关研究进展  

Advances in diffusion tensor imaging-based studies of brain white matter microstructure in children with Rolandic epilepsy related to cognitive deficits

作　　者：周小玲 刘衡 ZHOU Xiaoling;LIU Heng(Department of Radiology,Affliated Hospital of Zunyi Medical University,Guizhou University Intelligent Medical Imaging Engineering Research Center,Guizhou Provincial Medical Imaging Center,Zunyi 563000,China;Chengdu Women's and Children's Central Hospital,School of Medicine,University of Electronic Science and Technology of China,Chengdu 611731,China)

机构地区：[1]遵义医科大学附属医院放射科,贵州省高等学校智能医学影像工程研究中心,贵州省医学影像中心,遵义563000 [2]电子科技大学医学院附属妇女儿童医院-成都市妇女儿童中心医院,成都611731

出　　处：《磁共振成像》2024年第10期153-157,共5页Chinese Journal of Magnetic Resonance Imaging

基　　金：贵州省优秀青年科技人才培养计划项目(编号:黔科合平台人才[2021]5620)。

摘　　要：Rolandic癫痫(Rolandic epilepsy,RE)是儿童期最常见的特发性局灶性癫痫类型之一,常伴有认知功能障碍。尽管RE的发病机制尚不明确,但近年来,扩散张量成像(diffusion tensor imaging,DTI)技术为研究RE儿童脑白质微观结构提供了重要的无创手段。本文基于DTI技术对RE儿童脑白质微结构变化与认知障碍之间相关性的研究进行了综述,包括DTI参量指标方面的评估、脑白质连接的异常、大脑半球的偏侧化、DTI结构网络与RE全脑连接分析以及抗癫痫药物对RE脑结构的影响,具体探讨了不同脑白质纤维束的异常及其对认知功能的影响。通过综合分析这些研究结果,本文旨在为未来进一步探索RE的发病机制及早期干预策略提供科学依据。Rolandic epilepsy(RE)is one of the most common types of idiopathic focal epilepsy in childhood and is often associated with cognitive impairment.Although the pathogenesis of RE is not well understood,diffusion tensor imaging(DTI)has provided an important noninvasive method for the study of white matter microstructure in children with RE in recent years.This paper presented a review of studies based on DTI techniques in the correlation between cerebral white matter microstructural changes and cognitive impairment in children with RE,including five sections on assessment of DTI covariates,abnormalities in cerebral white matter connectivity,lateralisation of the cerebral hemispheres,analysis of the DTI structural network and whole-brain connectivity in RE,and effects of antiepileptic drugs on brain structure in RE.Abnormalities in different white matter fibre tracts and their effects on cognitive function were specifically explored.By comprehensively analysing the results of these studies,this paper aims to provide a scientific basis for further exploration of the pathogenesis of RE and early intervention strategies in the future.

关 键 词：Rolandic癫痫 脑白质 磁共振成像 扩散张量成像 认知障碍 

分 类 号：R445.2[医药卫生—影像医学与核医学] R749.1[医药卫生—诊断学]