杏仁核5-HT神经环路在失眠障碍及抑郁症共病机制中的功能磁共振成像研究进展  

Functional magnetic resonance imaging research progress of the 5-HT neural circuit to amygdala in the multimorbidity of insomnia disorder and depression

作　　者：张雪怡 贾淑蕾 谷宇昂 张淼 陈珂珂 孙永兵 周菁 武肖玲 李中林 邹智 尚菲菲 李会强 杨志萍 尤阳 李永丽 ZHANG Xueyi;JIA Shulei;GU Yuang;ZHANG Miao;CHEN Keke;SUN Yongbing;ZHOU Jing;WU Xiaoling;LI Zhonglin;ZOU Zhi;SHANG Feifei;LI Huiqiang;YANG Zhiping;YOU Yang;LI Yongli(Department of Medical Imaging,People's Hospital of Zhengzhou University/Henan Provincial People's Hospital,Zhengzhou 450003,China;Department of Medical Imaging,Xinxiang Medical University/Henan Provincial People's Hospital,Zhengzhou 450003,China;Department of Health Management,People's Hospital of Zhengzhou University/Henan Provincial People's Hospital,Henan Key Laboratory of Chronic Disease Health Management,Zhengzhou 450003,China;Department of Nuclear Medicine,Henan Provincial People's Hospital/Zhengzhou University People's Hospital,Zhengzhou 450003,China)

机构地区：[1]郑州大学人民医院/河南省人民医院医学影像科,郑州450003 [2]新乡医学院/河南省人民医院医学影像科,郑州450003 [3]郑州大学人民医院/河南省人民医院健康管理学科/河南省慢病健康管理重点实验室,郑州450003 [4]河南省人民医院/郑州大学人民医院核医学科,郑州450003

出　　处：《磁共振成像》2024年第10期165-170,共6页Chinese Journal of Magnetic Resonance Imaging

基　　金：国家自然科学基金项目(编号:82071884);河南省医学科技计划项目(编号:SBGJ202302011);河南省科技攻关计划项目(编号:242102311018)。

摘　　要：失眠障碍(insomnia disorder,ID)及抑郁症是影响患者日常生活及身心健康的常见疾病,ID与抑郁症存在双向关系,二者常共病出现,但具体共病机制不清。杏仁核是情绪环路的关键中枢,五羟色胺(5-hydroxytryptamine,5-HT)通过调控杏仁核活性参与情绪调节,杏仁核5-HT神经环路参与ID及抑郁症。本文阐述了杏仁核及杏仁核5-HT神经环路结构及功能在ID及抑郁症患者的功能磁共振成像(functional magnetic resonance imaging,fMRI)变化,旨在为探究杏仁核5-HT神经环路在ID及抑郁症共病中可能存在的机制提供客观的神经影像学依据。Insomnia disorder(ID)and depression are common diseases that affect patients'daily life and physical and mental health.There is a bidirectional relationship between ID and depression,and they often present as multimorbidity,but the mechanism is unclear.The amygdala is a key center of the emotional circuit,and 5-hydroxytryptamine(5-HT)participates in emotion regulation by regulating amygdala activity.5-HT neural circuit to amygdala is involved in ID and depression.In this review,we illustrated the changes in the structure and function of the amygdala and 5-HT neural circuit to amygdala in patients with ID and depression through functional magnetic resonance imaging(fMRI),with the aim of providing an objective neuroimaging basis for exploring the possible mechanisms of the 5-HT neural circuit to amygdala in the multimorbidity of ID and depression.

关 键 词：失眠障碍 抑郁症 杏仁核 五羟色胺 磁共振成像 正电子发射断层显像 

分 类 号：R445.2[医药卫生—影像医学与核医学] R749.1[医药卫生—诊断学]