原发性早泄中枢丘脑-额叶-躯体感觉皮层环路MRI研究进展  

Research progress of brain MRI on the central thalamo-frontal-somatosensory cortex circuit in lifelong premature ejaculation

作　　者：李倩[1] 陆加明 朱正阳 李欣[2] 张雯[2] 张鑫[2] 张冰[1,2] LI Qian;LU Jiaming;ZHU Zhengyang;LI Xin;ZHANG Wen;ZHANG Xin;ZHANG Bing(Medical School of Nanjing University,Nanjing 210093,China;Department of Medical Imaging,the Affiliated Drum Tower Hospital of Nanjing University Medical School,Nanjing 210008,China)

机构地区：[1]南京大学医学院,南京210093 [2]南京大学医学院附属鼓楼医院医学影像科,南京210008

出　　处：《磁共振成像》2024年第10期176-181,186,共7页Chinese Journal of Magnetic Resonance Imaging

基　　金：科技创新2030—“脑科学与类脑研究”重大项目(编号:2022ZD0211800)。

摘　　要：原发性早泄(lifelong premature ejaculation,LPE)是男性最常见的性功能障碍疾病,但中枢发病机制尚不明确。近年来,研究人员借助多模态磁共振成像(magnetic resonance imaging,MRI)技术检测和分析了LPE患者大脑结构和功能的特定变化,尤其是与奖赏系统相关的丘脑-额叶环路,以及参与射精周期的躯体感觉皮层。本文将基于丘脑-额叶-躯体感觉皮层环路对LPE患者的大脑MRI研究发现进行综述,探寻丘脑-额叶-躯体感觉皮层环路在LPE中枢神经系统中的作用机制,为开辟新的早泄评估和疗效评价方法提供科学依据。Lifelong premature ejaculation(LPE)is the most common sexual dysfunction disorder in men,yet its central pathogenesis remains unclear.In recent years,researchers have employed multimodal magnetic resonance imaging(MRI)techniques to detect and analyze specific changes in the brain structure and function of LPE patients.Their focus has particularly been on the thalamo-frontal circuit related to the reward system and the somatosensory cortex involved in the ejaculation cycle.This article reviews the findings from brain MRI studies of LPE patients based on the thalamus-frontal-somatosensory cortex circuit.It aims to explore the role and mechanisms of the thalamus-frontal-somatosensory cortex circuit in the central nervous system of LPE,providing a scientific basis for developing new methods for the assessment and evaluation of premature ejaculation.

关 键 词：原发性早泄 脑磁共振成像 静息态功能磁共振成像 任务态功能磁共振 丘脑 额叶 躯体感觉皮层 

分 类 号：R445.2[医药卫生—影像医学与核医学] R749.1[医药卫生—诊断学]