IVIM成像技术评估骨骼肌生理和病理状态的应用进展  

Application progress of IVIM imaging technology in evaluating physiological and pathological status of skeletal muscle

作　　者：田第娇 万兵 刘玥 张德文 王玟 黄倚天 TIAN Dijiao;WAN Bing;LIU Yue;ZHANG Dewen;WANG Wen;HUANG Yitian(Department of Radiology,Renhe Hospital affiliated to China Three Gorges University,Yichang 443001)

机构地区：[1]三峡大学附属仁和医院放射科,宜昌443001

出　　处：《磁共振成像》2024年第10期222-227,233,共7页Chinese Journal of Magnetic Resonance Imaging

基　　金：2022年度湖北省教育厅科学研究计划项目(编号:B2022032)。

摘　　要：骨骼肌是人体重要的运动器官,其功能与人类日常活动紧密相关,但临床检查骨骼肌病变的形态学表现相对于微观病理变化具有滞后性,而从微观角度评价骨骼肌的水分子运动及毛细血管灌注信息,近年来逐渐成为临床研究的热点。体素内不相干运动(intravoxel incoherent motion,IVIM)是一种双指数模式的磁共振扩散功能成像技术,它利用水分子扩散和毛细血管网循环的特点,为我们提供组织功能状态相关的重要信息,包括真扩散系数(D)、假扩散系数(D^(*))和灌注分数(f)等,该成像机制与骨骼肌生理特性正好契合。本文就IVIM成像原理及参数含义,结合骨骼肌的生理特征、在衰老和疾病中的改变,综述IVIM技术在骨骼肌生理性衰老退变、不同运动状态时骨骼肌损伤/修复的评估、常见肌肉疾病鉴别诊断和功能评估三个方面的应用研究,并对相关研究中的参数设置、临床意义及应用限制等问题进行讨论,旨在为IVIM技术在骨骼肌成像中的应用提供更多参考价值。Skeletal muscle is an important motor organ in human body,and its function is closely related to human daily activities.However,the morphological manifestations of skeletal muscle lesions are lagging behind the microscopic pathological changes.In recent years,the evaluation of water molecule movement and capillary perfusion information of skeletal muscle from a microscopic perspective has gradually become a hot spot in clinical research.Intravoxel incoherent motion(IVIM)is a dual-exponential MR diffusion imaging technique,which uses the characteristics of water molecule diffusion and capillary network circulation to provide us with important information related to tissue function,including true diffusion coefficient(D),false diffusion coefficient(D^(*))and perfusion fraction(F),etc.This imaging mechanism coincides with the physiological characteristics of skeletal muscle.Based on the principles and parameters of IVIM imaging,combined with the physiological characteristics of skeletal muscle and the changes in aging and diseases,this paper summarizes the application research of IVIM technology in three aspects:physiological aging and degeneration of skeletal muscle,evaluation of skeletal muscle injury/repair in different exercise states,differential diagnosis of common muscle diseases and functional evaluation,and discusses the parameter setting,clinical significance and application limitations in related research,aiming at providing more reference value for the application of IVIM technology in skeletal muscle imaging.

关 键 词：体素内不相干运动 骨骼肌 磁共振功能成像 磁共振成像 水分子扩散 微循环灌注 

分 类 号：R445.2[医药卫生—影像医学与核医学] R685[医药卫生—诊断学]