3D打印组织工程半月板的研究现状  

Research status of 3D printing tissue engineering meniscus

作　　者：李佳峒 黄显程 叶素芬 尤田[2] LI Jia-tong;HUANG Xian-cheng;YE Su-fen;YU Tian(Medical School,Shenzhen University,Shenzhen,Guangdong 518060,China;Shenzhen Hospital,Peking University,Shenzhen,Guangdong 518036,China)

机构地区：[1]深圳大学医学部,广东深圳518060 [2]北京大学深圳医院,广东深圳518036

出　　处：《中国矫形外科杂志》2024年第21期1976-1979,1986,共5页Orthopedic Journal of China

基　　金：深圳市卫生经济学会科研基金项目(编号:202353);深圳市科技计划项目(编号:JCYJ20220530160218040);深圳大学教学改革研究项目(编号:JG2022165);北京大学深圳医院临床研究项目(编号:LCYJ2020005);广东省体育局科技创新和体育文化发展项目(编号:GDSS2020N002);广东省自然科学基金项目(编号:2017A030310616);深圳市三名工程项目(编号:SZSM202211019);广东省医学科学技术研究基金项目(编号:A2017202;A2024319)。

摘　　要：半月板撕裂在骨科疾病中越来越常见,由于半月板的组织特殊性,通常通过保守治疗或者手术治疗撕裂的半月板来避免发展为骨关节炎。因为半月板缺乏血液供应,且具有不可再生性,所以无论是外伤性或者退行性病变,半月板切除后都会导致后期骨关节炎的发生。随着3D打印技术的兴起,给半月板修复带来了希望。当然,3D打印需要高精密的仪器和性能优良的3D打印墨水。本综述对目前用于生物打印的不同生物墨水(包括细菌纤维素)进行了深入的讨论,并概述了其进一步发展的前景。Meniscal tears are becoming increasingly common in orthopedic field.Due to its histological specificity,the torn meniscus is usually treated conservatively or surgically to prevent the development of osteoarthritis.Because the meniscus lacks blood supply and is nonrenewable,whether it is traumatic or degenerative tear the meniscectomy will lead to the occurrence of later osteoarthritis.With the rise of 3D printing technology,it has brought hope to meniscus repair.Of course,3D printing requires highly sophisticated instruments and the preparation of 3D printing inks with excellent properties.This review provides an in-depth discussion of the different bioinks currently used for bioprinting and outlines prospects for their further development.In addition,bacterial cellulose,which was found to be a 3D printing ink with good performance,is introduced in this paper.

关 键 词：半月板 3D打印 半月板撕裂 细菌纤维素 

分 类 号：R687[医药卫生—骨科学]