健康成年人腰椎椎体骨髓^(18)F-FDG生理性摄取规律的观察性研究  

Observational study of the physiological uptake of ^(18)F-FDG in lumbar vertebral bone marrow in healthy adults

作　　者：方菊 岳荣丽 黄楠 秦卓琦 成琪瑶 郑荣 郝新忠[1] 程艳[1] Fang Ju;Yue Rongli;Huang Nan;Qin Zhuoqi;Cheng Qiyao;Zheng Rong;Hao Xinzhong;Cheng Yan(Department of Nuclear Medicine,First Hospital of Shanxi Medical University,Taiyuan 030001,China)

机构地区：[1]山西医科大学第一医院核医学科,太原030001

出　　处：《国际放射医学核医学杂志》2024年第9期550-556,共7页International Journal of Radiation Medicine and Nuclear Medicine

摘　　要：目的分析健康成年人腰椎椎体骨髓^(18)F-氟脱氧葡萄糖(FDG)生理性摄取的规律.方法回顾性分析2010年6月至2018年6月在山西医科大学第一医院行^(18)F-FDG PET/CT检查的受检者中的323名健康成年人的临床资料,其中男性161名、女性162名,年龄(54.8±13.9)岁,范围30~78岁.将受检者按照年龄段分为30~39岁组、40~49岁组、50~59岁组、60~69岁组和70~79岁组,各组男性和女性人数分别为30和30名、36和40名、31和30名、32和30名、32和32名.分别在腰2、腰3、腰4椎体上勾画感兴趣区,测量其平均标准化摄取值(SUV_(mean)).腰椎椎体骨髓SUV_(mean)定义为这3个椎体SUV_(mean)的均值,并用来表示腰椎椎体骨髓^(18)F-FDG摄取程度.采用Pearson或Spearman秩相关分析分析受检者年龄与SUV_(mean)的相关性;比较不同年龄组及性别的受检者间SUV_(mean)的差异,组内比较采用独立样本t检验或Mann-Whitney U检验,组间比较采用Kruskal-Wallis H检验和Bonferroni法.结果所有受检者、男性受检者和女性受检者腰椎椎体骨髓SUV_(mean)均与年龄呈负相关(r=-0.520,-0.451、-0.579,均P<0.001),但SUV_(mean)并不随年龄增长呈均匀线性下降.在女性受检者中,各年龄组间腰椎椎体骨髓SUV_(mean)的比较结果显示,50~59岁组低于40~49岁组[(1.45±0.32)对(1.75±0.44)]、70~79岁组低于60~69岁组[(1.18±0.17)对(1.45±0.31)],且差异均有统计学意义(H=2.848、3.114,均P<0.05),而在30~39岁组与40~49岁组间、50~59岁组与60~69岁组间腰椎椎体骨髓SUV_(mean)的差异均无统计学意义(H=0.371、0.220,均P>0.05),提示女性腰椎椎体骨髓SUV_(mean)在随年龄增长下降的过程中出现两个平台期,平台期内腰椎椎体骨髓SUV_(mean)未随年龄增长而降低.在男性受检者中,70~79岁组腰椎椎体骨髓SUV_(mean)低于60~69岁组[(1.14±0.22)对(1.42±0.34)],且差异有统计学意义(H=3.210,P<0.05),其余各相邻年龄组间的差异均无统计学意义(H=1.631、0.724、0.585,均PObjective To analyze the patterns of physiological uptake of ^(18)F-fluorodeoxyglucose(FDG)in lumbar vertebral bone marrow in healthy adults.Methods A retrospective analysis was performed on 323 healthy adults who underwent ^(18)F-FDG PET/CT examination at the First Hospital of Shanxi Medical University from June 2010 to June 2018.Among the participants,161 were males and 162 were females,respectively,aged(54.8±13.9)years,ranging from 30 to 78 years.The subjects were divided into 30–39-year-old group,40–49-year-old group,50–59-year-old group,60–69-year-old group,and 70–79-year-old group;the numbers of males and females in each group were 30 and 30,36 and 40,31 and 30,32 and 30,and 32 and 32,respectively.The regions of interest were delineated on lumbar 2–4 vertebrae,and their mean standardized uptake value(SUV_(mean))were measured.Lumbar vertebral bone marrow SUV_(mean),defined as the average of these three vertebral bodies,was used to indicate the degree of ^(18)F-FDG uptake of the lumbar vertebral bone marrow.Pearson's or Spearman's rank correlation analysis was employed to assess the correlation between participants'age and SUV_(mean).Differences in SUV_(mean) among various age and gender groups were compared,with within-group comparisons conducted using independent sample t-test or the Mann-Whitney U test and between-group comparisons performed using the Kruskal-Wallis H test and the Bonferroni method.Results The lumbar vertebral bone marrow SUV_(mean) were negatively correlated with age in all participants,males,and females,respectively(r=−0.520,−0.451,−0.579;all P<0.001).However,the SUV_(mean) did not decrease uniformly and linearly with age.Among female participants,the lumbar vertebral bone marrow SUV_(mean) of the 50–59-year-old group(1.45±0.32)was lower than that of the 40–49-year-old group(1.75±0.44),and the lumbar vertebral bone marrow SUV_(mean) of the 70–79 yearold group(1.18±0.17)was lower than that of the 60–69-year-old group(1.45±0.31),with both differences being st

关 键 词：骨髓 腰椎 成年人 正电子发射断层显像术 体层摄影术 X线计算机 氟脱氧葡萄糖F18 

分 类 号：R817.4[医药卫生—影像医学与核医学]