肠道微生态研究技术和研究策略  

Research technologies and strategies of gut microecology

作　　者：罗菀蓉 高杨[1] 张文婕 朱亦君 Luo Wanrong;Gao Yang;Zhang Wenjie;Zhu Yijun(Institute of Precision Medicine,the First Affiliated Hospital,Sun Yat-sen University,Guangzhou 510080,China)

机构地区：[1]中山大学附属第一医院精准医学研究院,广州510080

出　　处：《中华炎性肠病杂志（中英文）》2024年第5期329-334,共6页Chinese Journal of Inflammatory Bowel Diseases

基　　金：国家自然科学基金(K0115344)。

摘　　要：肠道微生态是由肠道微生物及其生活环境共同构成的复杂生态系统,其与宿主的消化、代谢、免疫等多种生理功能密切相关,是维持宿主健康的重要因素之一。因此,研究肠道微生态对理解疾病的发生机制、预防和治疗具有至关重要的作用。近年来,随着分子生物学及生物信息学等技术的飞速进步,肠道微生态研究取得显著进展。本文回顾了当前应用于肠道微生态研究的关键技术和策略,以供参考。Gut microecology is a complex ecosystem composed of gut microbiota and the host environment.It is a crucial factor for maintaining the host's health because it is closely related to various physiological functions,such as digestion,metabolism and immunity.Therefore,studying the gut microecology is essential for understanding the pathogenesis,prevention and treatment of disease.Recently,with the rapid advancement of molecular biology and bioinformatics technologies,significant progress has been made in the research of the gut microecology.In this review,the important technologies and strategies currently applied in gut microecology research are summarized for reference.

关 键 词：肠道微生物 微生物培养 高通量测序 多组学 微生态 

分 类 号：R37[医药卫生—病原生物学]