钙调蛋白基因突变诱导心律失常机制的研究进展  

Research progress on the mechanism of arrhythmia induced by calmodulin gene mutation

作　　者：赵文诗 郝明杰 刘源 徐羽佳[1,3] 王超 郝丽英 苏敬阳[1] ZHAO Wen-shi;HAO Ming-jie;LIU Yuan;XU Yu-jia;WANG Chao;HAO Li-ying;SU Jing-yang(Department of Clinical Pharmacology,School of Pharmacy,China Medical University,Shenyang 110122,China;Department of Pharmaceutical Toxicology,School of Pharmacy,China Medical University,Shenyang 110122,China;China Medical University-Queen's University Belfast Joint College,China Medical University,Shenyang 110122,China)

机构地区：[1]中国医科大学药学院临床药理学教研室,辽宁沈阳110122 [2]中国医科大学药学院药物毒理学教研室,辽宁沈阳110122 [3]中国医科大学中英联合学院,辽宁沈阳110122

出　　处：《解剖科学进展》2024年第4期443-446,448,共5页Progress of Anatomical Sciences

基　　金：国家自然科学基金面上项目(31471091);中国博士后科学基金面上项目(2021M693914);医学电生理学教育部重点实验室(西南医科大学)开放基金(KeyME-2019-07);国家级大学生创新训练项目(202110159007)。

摘　　要：钙调蛋白(CaM)是一种重要的细胞内蛋白,与Ca^(2+)结合后通过与蛋白质和多肽的广泛相互作用参与许多生物活动,例如炎症反应、神经生长、细胞代谢、细胞凋亡、细胞运动、短期和长期记忆、肌肉收缩、免疫反应和肿瘤细胞增殖等,并且在心血管疾病的发生发展中起着重要作用。CaM基因突变会引起危及生命的心律失常综合征,本文以期为CaM成为心律失常防治的新靶点以及新药研发提供参考依据。Calmodulin(CaM)is an important intracllular protein that binds to Ca^(2+)and is involved in many biological activities through a wide range of interactions with proteins and peptides,such as inflammatory response,nerve growth,metabolism,apoptosis,cell movement,short and long term memory,muscle contraction,immune response and tumor cell proliferation,also plays an important role in the occurrence and development of cardiovascular diseases.CaM gene mutations can cause life-threatening arrhythmia syndrome.This study is expected to provide reference for CaM to become a new target for the prevention and treatment of arrhythmia and the research and development of new drugs.

关 键 词：新药研发 心血管疾病 肌肉收缩 细胞代谢 免疫反应 心律失常 新靶点 细胞凋亡 

分 类 号：R541.7[医药卫生—心血管疾病]