血清尿调蛋白与高血压肾损害的相关性  

Association between serum uromodulin and hypertensive renal damage

作　　者：王忠丽[1] 王立立[2] 张婷婷 翟建龙 和丽丽[3] 左庆娟 马赛[4] 张国瑞[5] 郭艺芳[3] WANG Zhongli;WANG Lili;ZHANG Tingting;ZHAI Jianlong;HE Lili;ZUO Qingjuan;MA Sai;ZHANG Guorui;GUO Yifang(Department of Physical Examination Center,Hebei General Hospital,Shijiazhuang,Hebei 050000,China;Department of Cardiology,Hebei General Hospital,Shijiazhuang,Hebei 050000,China;Department of Geriatric Cardiology,Hebei General Hospital,Shijiazhuang,Hebei 050000,China;Department of Internal Medicine,Hebei General Hospital,Shijiazhuang,Hebei 050000,China;Department of Cardiology, The Third Hospital of Shijiazhuang)

机构地区：[1]河北省人民医院体检中心,河北石家庄050000 [2]河北省人民医院心内科,河北石家庄050000 [3]河北省人民医院老年心内科,河北石家庄050000 [4]河北省人民医院内科,河北石家庄050000 [5]石家庄市第三医院心内科

出　　处：《中华高血压杂志（中英文）》2024年第10期964-970,共7页Chinese Journal of Hypertension

基　　金：河北省创新能力提升计划(199776249D);河北省重点研发计划(19277787D);河北省医学科学研究课题计划(20242284)。

摘　　要：目的 探讨血清尿调蛋白(UMOD)与高血压肾损害的相关性。方法 2022年5月至2022年12月于河北省人民医院纳入66例原发性高血压伴肾损害患者,年龄和性别匹配的59例原发性高血压无肾损害患者和58例健康对照者。收集受试者的血清样本,测定血清中UMOD水平。采用多因素logistic回归分析血清UMOD与肾损害的关系。结果 从健康人到高血压无肾损害患者再到高血压伴肾损害患者,血清UMOD逐渐降低[分别为(133.18±43.14)、(83.12±20.00)、(69.04±18.68)μg/L,F=98.395,P<0.001]。Spearman相关分析显示:血清UMOD水平与血清肌酐及收缩压呈负相关(r_(s)=-0.411,-0.341,均P<0.001),与估算的肾小球滤过率(eGFR)呈正相关(r_(s)=0.403,P<0.001)。多因素logistic回归分析显示,校正混杂因素后,血清UMOD降低是发生高血压的独立危险因素(OR=0.927,95%CI 0.898~0.957);也是发生高血压肾损害的独立危险因素(OR=0.870,95%CI 0.813~0.933);同时也是高血压患者发生肾损害的独立危险因素(OR=0.949,95%CI 0.924~0.975)。结论 血清UMOD降低可能是高血压肾损害的危险因素之一。Objective To investigate the association between serum uromodulin(UMOD) and hypertensive renal damage.Methods From May 2022 to December 2022,66 essential hypertensive patients with renal damage,59 age and gender-matched essential hypertensive patients without renal damage and 58 healthy controls were enrolled in Hebei General Hospital.Serum samples were collected and the levels of UMOD were measured.Multivariate logistic regression analysis was used to analyze the relationship between serum UMOD and renal damage.Results Serum UMOD gradually decreased from healthy individuals to essential hypertensive patients without renal damage to essential hypertensive patients with renal damage [(133.18±43.14),(83.12±20.00),(69.04±18.68) μg/L,respectively,F=98.395,P<0.001].Spearman correlation analysis showed that serum UMOD was negatively correlated with creatinine(r_s=-0.411,P<0.001) and systolic blood pressure(r_s=-0.341,P<0.001),and positively correlated with estimated glomerular filtration rate(eGFR)(r_s=0.403,P<0.001).After adjusting for confounding factors,multivariate logistic regression analysis showed that the decrease of serum UMOD was an independent risk factor for hypertension(OR=0.927,95%CI 0.898-0.957),and an independent risk factor for hypertensive renal damage(OR=0.870,95%CI 0.813-0.933),and it was also an independent risk factors for the progression of hypertension to hypertensive renal damage(OR=0.949,95%CI 0.924-0.975).Conclusion The decrease of serum UMOD may be one of the risk factors for hypertensive renal damage.

关 键 词：尿调蛋白 血清 高血压 高血压肾损害 相关性 

分 类 号：R544.1[医药卫生—心血管疾病] R692[医药卫生—内科学]