NRP1在免疫系统中的调节作用及机制  

Regulatory role and mechanism of neuropilin 1 in immune system

作　　者：孙雨欣 时鹏 年娣 SUN Yuxin;SHI Peng;NIAN Di(Department of Clinical medicine,Bengbu Medical University,Bengbu 233030,China;Department of Neurology,the First Affiliated Hospital of Bengbu Medical University,Bengbu 233004,China;Department of Nuclear Medicine,Department of Laboratory Medicine,Bengbu Medical University,Bengbu 233000,China)

机构地区：[1]蚌埠医科大学临床医学院,蚌埠233030 [2]蚌埠医科大学第一附属医院神经内科,蚌埠233004 [3]蚌埠医科大学检验系核医学教研室,蚌埠233000

出　　处：《国际免疫学杂志》2024年第5期541-547,共7页International Journal of Immunology

基　　金：安徽省高校自然科学研究重点项目(KJ2020A0570);安徽省高校自然科学研究重大项目(KJ2021ZD0084);安徽省临床医学研究转化专项项目(202304295107020075);蚌埠医科大学大学生创新创业训练计划项目(202010367063,202110367096,bydc2023004)。

摘　　要：神经纤毛蛋白(neuropilins,NRPs)是一种多功能非酪氨酸激酶表面糖蛋白,最初被定义为轴突引导和神经发育因子,调节神经系统发育。近年研究表明NRP1常在各种免疫细胞和肿瘤细胞中表达,其与其配体的相互作用在机体免疫应答、自身免疫性疾病及肿瘤发展中起着关键作用,有望成为多种疾病的生物标志物。文章就NRP1与其配体的免疫调节机制及其在相关自身免疫性疾病和肿瘤中的作用展开综述。Neuropilins(NRPs)are multifunctional non-tyrosine kinase surface glycoproteins.They were originally defined as axon-directed and neurodevelopmental factors that regulate the development of nervous system.Recent studies have shown that NRP1 is frequently expressed in various immune cells and tumor cells.Interaction NRP1 with its ligands plays a key role in immune response of the body and in progressions of autoimmune diseases and tumors.NRP1 is expected to be a biomarker for a variety of diseases.This review summarized the immunomodulatory mechanisms of NRP1 and its ligands and their roles in related autoimmune diseases and tumors.

关 键 词：神经纤毛蛋白-1 免疫调节 自身免疫性疾病 肿瘤 

分 类 号：R392[医药卫生—免疫学]