固有淋巴细胞与支气管哮喘的研究进展  

Research progress on the relationship between innate lymphocytes and bronchial asthma

作　　者：郭子涵 刘欣怡 左安力 鲁德玕[1] GUO Zihan;LIU Xinyi;ZUO Anli;LU Degan(Department of Respiratory,the First Affiliated Hospital of Shandong First Medical University&Shandong Provincial Qianfoshan Hospital,Shandong Institute of Respiratory Diseases,Shandong Institute of Anesthesia and Respiratory Critical Medicine,Jinan 250000,China;Department of Respiratory and Critical Care Medicine,Affiliated Hospital of Shandong Universitly of Traditional Chinese Medicine,Jinan 250000,China)

机构地区：[1]山东第一医科大学第一附属医院(山东省千佛山医院)呼吸病学、山东省呼吸疾病研究所、山东省麻醉与呼吸危重症研究所,济南250000 [2]山东中医药大学附属医院呼吸与危重症医学科,济南250000

出　　处：《国际免疫学杂志》2024年第5期548-553,共6页International Journal of Immunology

基　　金：山东省自然科学基金联合基金(ZR2021LSW015);济南市呼吸疾病临床医学研究中心项目(202132002)。

摘　　要：哮喘是21世纪全球公共健康问题之一,其在我国发病率高且呈明显上升趋势,疾病负担重。哮喘是一种气道炎症性疾病,容易反复发作,可出现气道高反应性、黏液分泌增多、气道重塑以及气流受限等特征。引发哮喘的因素较多,如遗传易感性和环境因素等。近10年来,固有淋巴细胞(innate lymphocyte,ILCs)的发现使我们对哮喘的发病机制有了进一步的认识,ILCs可分为不同亚型。文章阐述了ILCs在哮喘发病中的最新研究进展以及ILCs在哮喘防治中的潜在价值。Asthma remains a public health problem worldwide in the 21st century and the incidence of asthma is high and on the rise in China,resulting in heavy disease burden.As an airway inflammatory disease with recurrent attacks,asthma is characterized by airway hyper-responsiveness,increased mucus secretion,airway remodeling,and airflow limitation.The factors which cause asthma are diverse and include genetic susceptibility and environmental ones.With the discovery of innate lymphocytes(ILCs)and its different subtypes,the pathogenesis of asthma was further understood.Therefore,this paper reviews the latest research progression in the role of ILCs in asthma and the value of ILCs potentially used in the prevention and treatment of asthma.

关 键 词：支气管哮喘 固有淋巴细胞 免疫机制 

分 类 号：R562.25[医药卫生—呼吸系统]