HLA-G在妊娠期区域性耐受建立与维持中的作用研究进展  

Research progress on the role of HLA-G in the establishment and maintenance of regional tolerance during pregnancy

作　　者：白娇娇 黄丹 于浩天 BAI Jiaojiao;HUANG Dan;YU Haotian(The Eighth Medical Center of the Chinese PLA General Hospital,Beijing 100089,China;Hebei Northern University,Zhangjiakou 075000,China)

机构地区：[1]中国人民解放军总医院第八医学中心,北京100089 [2]河北北方学院,张家口075000

出　　处：《国际免疫学杂志》2024年第5期561-566,共6页International Journal of Immunology

基　　金：军后综(2021)276号,计生专项编号145BHQ090003076X。

摘　　要：人类白细胞抗原G(human leukocyte antigen G,HLA-G)最初发现于母胎界面胎盘滋养层中,在母胎免疫耐受形成中发挥着重要角色。最近的研究逐渐揭示了HLA-G分子与免疫系统的相关性,特别是其在妊娠中的调控作用。文章综述了HLA-G基因的功能和免疫调节机制及与母胎耐受与维持的相关性的最新研究进展。Human leukocyte antigen G(HLA-G)was initially discovered in the placental trophoblasts at the maternal-fetal interface and plays a crucial role in the formation of maternal-fetal immune tolerance.Recent research has gradually revealed the relevance of HLA-G molecules to the immune system,particularly their regulatory role during pregnancy.This article provides an overview of the functions of HLA-G genes,the mechanisms of immune regulation,and the latest research advances regarding their relevance to the establishment and maintenance of maternal-fetal tolerance.

关 键 词：人类白细胞抗原G 免疫特性 母胎耐受 不良妊娠 

分 类 号：R714.2[医药卫生—妇产科学]