MEBT/MEBO治疗慢性难愈合创面作用机制研究进展  

Progress of Research on Mechanism of Action of MEBT/MEBO in Treating Chronic Refractory Wound

作　　者：赵权 谢嘉敏 唐乾利[4] 黄金梅 ZHAO Quan;XIE Jiamin;TANG Qianli;HUANG Jinmei(Department of General Surgery,Fangchenggang Hospital of Traditional Chinese Medicine,Fangchenggang,Guangxi 530021,China;Department of Dermatology,Fangchenggang Hospital of Traditional Chinese Medicine,Fangchenggang,Guangxi 530021,China;Grade 2022,Faculty of TCM Surgery,Guangxi University of Chinese Medicine,Nanning,Guangxi 530200,China;Graduate School of Guangxi University of Chinese Medicine,Nanning,Guangxi 530200,China)

机构地区：[1]防城港市中医医院普通外科,广西防城港530021 [2]防城港市中医医院皮肤科,广西防城港530021 [3]广西中医药大学,广西南宁530200 [4]广西中医药大学研究生院,广西南宁530200

出　　处：《中国烧伤创疡杂志》2024年第6期421-424,共4页The Chinese Journal of Burns Wounds & Surface Ulcers

基　　金：国家自然科学基金面上项目(81774327);广西重点研发计划项目(桂科AB21196013);防城港市科技重点研发计划项目(防科AB21014040);广西中医药大学研究生创新性课题(YCBXJ2021014)。

摘　　要：慢性难愈合创面具有高致残率、高致死率等特点,给患者造成了极大的痛苦。近年来,创疡再生医疗技术(MEBT/MEBO)因能够通过调控创面再生修复过程中的炎症反应、细胞增殖和组织重塑等阶段促进肉芽组织生长、血管生成、上皮组织移行等而加快创面愈合,被广泛应用于慢性难愈合创面的临床治疗。基于此,本文主要对MEBT/MEBO调控炎症反应、细胞增殖和组织重塑3个阶段促进慢性难愈合创面修复的相关机制予以综述,以期为MEBT/MEBO的进一步临床应用提供理论依据及思路。Chronic refractory wound has the characteristics of high disability rate and high fatality rate,resulting in huge pain for patients.In recent years,the regenerative medical technology for wounds and ulcers(MEBT/MEBO)has been widely used in the clinical treatment of chronic refractory wound,because of its effectiveness of accelerating wound healing by regulating the inflammatory response,cell proliferation and tissue remodeling in the process of wound regeneration and repair to promote the growth of granulation tissue,angiogenesis,and epithelial tissue migration.Based on this,this paper mainly reviewed the mechanism of action of MEBT/MEBO in regulating the inflammatory response,cell proliferation and tissue remodeling to promote the healing of chronic refractory wound,with the view of providing theoretical basis for the further clinical application of MEBT/MEBO.

关 键 词：慢性难愈合创面 修复 创疡再生医疗技术 作用机制 综述 

分 类 号：R641[医药卫生—外科学]