三碘甲状腺原氨酸、皮质醇、免疫球蛋白E在烧伤患者病情及预后评估中的应用  

Application of Triiodothyronine,Cortisol and Immunoglobulin E in the Evaluation of Disease Condition and Prognosis of Burn Patients

作　　者：张承钗 陈娟[1] 黄咏 许益云 ZHANG Chengchai;CHEN Juan;HUANG Yong;XU Yiyun(Department of Clinical Laboratory,Fuding Hospital,Fuding,Fujian 352220,China)

机构地区：[1]福鼎市医院检验科,福建福鼎352220

出　　处：《中国烧伤创疡杂志》2024年第6期442-446,共5页The Chinese Journal of Burns Wounds & Surface Ulcers

摘　　要：目的探讨三碘甲状腺原氨酸、皮质醇、免疫球蛋白E在烧伤患者病情及预后评估中的应用价值。方法选取2022年1月至2023年9月福鼎市医院收治的150例烧伤患者(设为研究组),以及同期于福鼎市医院接受体检的58名健康体检者(设为对照组)作为研究对象,并根据患者病情严重程度及预后将研究组患者分为轻度亚组、中度亚组与重度亚组及预后良好亚组与预后不良亚组,分析烧伤患者与健康体检者以及不同严重程度与预后的烧伤患者三碘甲状腺原氨酸、皮质醇、免疫球蛋白E水平以及三碘甲状腺原氨酸、皮质醇、免疫球蛋白E与烧伤患者预后的相关性。结果研究组研究对象三碘甲状腺原氨酸水平明显低于对照组(t=21.171,P<0.001),皮质醇、免疫球蛋白E水平明显高于对照组(t=136.702、13.472,P均<0.001)。重度亚组患者三碘甲状腺原氨酸水平明显低于中度亚组与轻度亚组(q=22.112、54.410,P均<0.001),且中度亚组患者三碘甲状腺原氨酸水平明显低于轻度亚组(q=36.631,P<0.001);重度亚组患者皮质醇、免疫球蛋白E水平明显高于中度亚组与轻度亚组(皮质醇:q=93.329、34.983,P均<0.001;免疫球蛋白E:q=12.671、6.687,P均<0.001),且中度亚组患者皮质醇、免疫球蛋白E水平明显高于轻度亚组(q=59.961、6.607,P均<0.001)。预后不良亚组患者三碘甲状腺原氨酸水平明显低于预后良好亚组(t=27.723,P<0.001),皮质醇、免疫球蛋白E水平明显高于预后良好亚组(t=19.324、3.277,P<0.001,P=0.001)。Spearman相关性分析结果显示,三碘甲状腺原氨酸与烧伤患者预后呈正相关性(r=1.872,P<0.001),皮质醇、免疫球蛋白E与烧伤患者预后呈负相关性(r=-0.902、-0.876,P均<0.001)。结论三碘甲状腺原氨酸、皮质醇、免疫球蛋白E均可作为早期评估烧伤患者病情严重程度及预后的生物学指标进行临床推广。Objective To study the application value of triiodothyronine,cortisol and immunoglobulin E in the evaluation of disease condition and prognosis of burn patients.Methods 150 burn patients(study group)and 58 healthy subjects(control group)undergoing physical health check in Fuding Hospital between January 2022 and September 2023 were selected as the research subjects.According to the disease severity and prognosis,the patients in the study group were divided into mild subgroup,moderate subgroup,severe subgroup,good prognosis subgroup and poor prognosis subgroup.The levels of triiodothyronine,cortisol and immunoglobulin E were analyzed in burn patients and healthy subjects,as well as in burn patients with different severity and prognosis,and also the correlation of triiodothyronine,cortisol,immunoglobulin E with the prognosis of burn patients were studied.Results The triiodothyronine level in the study group was significantly lower than that in the control group(t=21.171,P<0.001),and the levels of cortisol and immunoglobulin E were signifi⁃cantly higher in the study group(t=136.702 and 13.472,both P<0.001).Patients in the severe subgroup had significantly lower levels of triiodothyronine respectively compared with patients in the moderate subgroup and the mild subgroup(q=22.112 and 54.410,both P<0.001),and patients in the moderate subgroup had significantly lower levels of triiodothyro⁃nine than patients in the mild subgroup(q=36.631,P<0.001);patients in the severe subgroup had significantly higher levels of cortisol and immunoglobulin E respectively compared with patients in the moderate subgroup and the mild subgroup(cortisol:q=93.329 and 34.983,both P<0.001;immunoglobulin E:q=12.671 and 6.687,both P<0.001),and cortisol and immunoglobulin E levels of patients in the moderate subgroup were significantly higher than those in the mild subgroup(q=59.961 and 6.607,both P<0.001).Patients in the poor prognosis subgroup had significantly lower levels of triiodothyronine than patients in the good prognosis subgroup(t=2

关 键 词：三碘甲状腺原氨酸 皮质醇 免疫球蛋白E 烧伤 预后 相关性 

分 类 号：R644[医药卫生—外科学]