慢性阻塞性肺疾病患者的认知功能评价及其影响因素  

Evaluation of cognitive function and analysis of related influencing factors in patients with chronic obstructive pulmonary disease

作　　者：王晶[1] 闫黎明[2] 葛永春[1] 陈婕 高云秀[1] WANG Jing;YAN Liming;GE Yongchun;CHEN Jie;GAO Yunxiu(Department of Respiration and ICU,Binzhou Medical University Hospital,Binzhou 256603,Shandong,P.R.China;Department of Outpatient,Binzhou Medical University Hospital,Binzhou 256603,Shandong,P.R.China)

机构地区：[1]滨州医学院附属医院呼吸与危重症医学科,山东滨州256603 [2]滨州医学院附属医院门诊部,山东滨州256603

出　　处：《滨州医学院学报》2024年第5期401-403,417,共4页Journal of Binzhou Medical University

基　　金：滨州医学院附属医院护理科研计划(BYFYHL-201908)。

摘　　要：目的 探讨慢性阻塞性肺疾病(COPD)的认知功能及其相关影响因素,为COPD认知功能障碍的防治提供循证依据。方法 选取2021年6月至2022年6月在某医院呼吸与危重症医学科住院治疗的COPD患者作为COPD组,收集患者一般资料、血气分析和肺功能相关指标,通过简易智能精神状态检查量表(MMSE)评价认知功能,根据MMSE评分,将COPD患者分为有认知功能障碍组(MMSE<27)和无认知功能障碍组(MMSE≥27)。多因素Logistic回归分析影响COPD患者认知功能障碍的因素。结果 最终纳入COPD患者80例,其中有认知功能障碍组56例和无认知功能障碍组24例。相比无认知功能障碍组,有认知功能障碍组FEV_(1)更低,P<0.05。两组血气分析检查提示PH、氧分压(PO_(2))、二氧化碳分压(PaCO_(2))等差异均无统计学意义。经多因素Logistic回归分析显示,年龄、第一秒用力呼气容积(FEV1)是COPD患者继发认知功能障碍的危险因素,均P<0.05。结论 COPD患者存在不同程度的认知功能障碍,早期干预和改善肺功能有助于防治COPD患者的认知功能障碍。Objective To investigate the cognitive function and its related factors in patients with chronic obstructive pulmonary disease(COPD),and to provide evidence-based reference for the prevention and treatment of cognitive impairment in COPD.Methods Patients with COPD who were hospitalized in the Department of Respiratory and Critical Care Medicine of a hospital from June 2021 to June 2022 were randomly included as the COPD group.General data,blood gas analysis and related indicators of lung function were collected,and cognitive function was evaluated by the simple Mini-Mental State Examination(MMSE).COPD was divided into the cognitive impairment group(MMSE<27)and the non-cognitive impairment group(MMSE≥27).Multivariate Logistic regression was used to analyze factors affecting cognitive dysfunction in COPD patients.Results Eighty patients with COPD were included,including 56 patients with cognitive impairment and 24 patients without cognitive impairment.Compared with the group without cognitive impairment,the group with cognitive impairment had significantly lower FEV1(P<0.05).There was no significant difference in PH,PO_(2) and PaCO_(2) between the two groups.Multivariate Logistic regression analysis showed that age and FEV_(1) were the risk factors of cognitive impairment in COPD patients(P<0.05).Conclusion COPD patients have different degrees of cognitive impairment.Early intervention and improvement of pulmonary function are helpful to prevent and treat the cognitive impairment of COPD patients.

关 键 词：慢性阻塞性肺疾病 认知功能 危险因素 

分 类 号：R473.5[医药卫生—护理学]