水凝胶生物粘合剂用于软组织止血修复的研究进展  

Research Progress of Hydrogel Bioadhesives for Soft TissueHemostasis and Repair

作　　者：李甲 李淑 林钰洋 邢君 李玲[1] 王彩 郑敏[1] LI Jia;WANG Cai;ZHENG Min(School of Biomedical Engineering and Imaging,Xianning Medical College,Hubei University of Science and Technology,Xianning Huibei 437100,China)

机构地区：[1]湖北科技学院医学部生物医学工程与医学影像学院,湖北咸宁437100

出　　处：《湖北科技学院学报（医学版）》2024年第6期549-554,共6页Journal of Hubei University of Science and Technology(Medical Sciences)

基　　金：湖北科技学院博士启动基金(BK202201,BK202307);湖北省自然基金青年项目(2022CFB755,2023AFB538);湖北省教育厅科学研究计划中青年人才项目(Q20222804);国家自然科学基金青年项目(52303182)。

摘　　要：及时的伤口干预处理对预防伤口感染、促进组织结构和功能恢复至关重要。目前临床手术中最常采用缝合线、钉合器进行伤口闭合处理。然而,这些传统的伤口缝合方式操作复杂繁琐且易对软组织造成二次损伤,尤其不适用于肝脏、脾脏等脆弱软组织以及急性主动脉破裂和无法控制的心脏大出血等问题。鉴于这些不足,水凝胶生物粘合剂作为缝合线和钉合器的理想替代品引起了人们的极大关注。本文概括总结了近些年来水凝胶生物粘合剂在伤口止血和组织愈合等方面的研究进展,并对水凝胶生物粘合剂未来的发展趋势进行了展望,其水下粘附性能和降解性能仍需迫切解决。Timely wound intervention is essential to prevent wound infection and promote the recovery of tissue structure and function.At present,sutures and staples are most commonly used in clinical surgery for wound closure treatment.However,these traditional wound suture methods are complex and cumbersome to operate,and are prone to secondary damage to soft tissues,especially not suitable for delicate soft tissues such as the heart and spleen,as well as acute aortic rupture and uncontrollable cardiac hemorrhage.Given these shortcomings,hydrogel bioadhesives have been attracted a great deal of attention and considered as an ideal alternative to sutures and staples.In this paper,the research progress of hydrogel bioadhesives in wound hemostasis and tissue healing in recent years was summarized,and the future development trend of hydrogel bioadhesives was prospected.In conclusion,the underwater adhesion and degradation properties of hydrogel bioadhesives still need to be solved urgently.

关 键 词：出血 组织损伤 水凝胶生物粘合剂 伤口止血 组织愈合 

分 类 号：R973.1[医药卫生—药品]