Recognition and acquisition of FakB2-loaded exogenous fatty acid(eFA)by a streptococcal FakA kinase  

链球菌通过FakA/FakB2系统识别与摄取外源脂肪酸

作　　者：Haiyi Chen Yu Shi Man Huang Ting Lu Huimin Zhang Chun Zhou Tingjun Hou Youjun Feng 陈海轶;史钰;黄曼;卢挺;张会敏;周春;侯廷军;冯友军

机构地区：[1]Key Laboratory of Multiple Organ Failure,Ministry of Education,Departments of Microbiology and General Intensive Care Unit of the Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310058,China [2]College of Pharmaceutical Sciences,Zhejiang University,Hangzhou 310058,China [3]Cancer Center at Illinois,University of Illinois at Urbana-Champaign,Urbana IL 61801,USA [4]Department of Bioengineering,University of Illinois at Urbana-Champaign,Urbana IL 61801,USA [5]School of Public Health,Zhejiang University School of Medicine,Hangzhou 310058,China [6]Department of Clinical Laboratory,Shenzhen Third People’s Hospital,National Clinical Research Center for Infectious Diseases,The Second Affiliated Hospital of Southern University of Science and Technology,Shenzhen 518444,China

出　　处：《Science Bulletin》2024年第21期3355-3360,共6页科学通报（英文版）

基　　金：supported by the National Key Research&Development Program of China(2022YFC2303900 and 2022YFC3704700);the National Natural Science Foundation of China(32141001 and 31830001);the National Science Fund for Distinguished Young Scholar(32125003);China Postdoctoral Science Foundation(2022M712797).

摘　　要：Fatty acids (FAs) are building blocks required for the threedomains of life. The machinery of type II fatty acid synthesis is longrecognized as a druggable pathway against deadly infections withdrug-resistant bacterial pathogens [1]. However, an everincreasing body of exogenous FAs (eFA) utilization routes posesthe possibility of replacing bacterial de novo FA synthesis, whichmight compromise the FAS II-directed antimicrobials, like cerulenin[2–4]. As for Gram-negative species, the paradigm executorof an eFA recycling denotes an acyl-ACP synthetase (AasS) of thezoonotic pathogen Vibrio harveyi [5]. In contrast, a unique twocomponent system of fatty acid kinase called FakA/B [6], is exclusively present in Staphylococcus and Enterococcus/Streptococcus,two important lineages of Gram-positive bacterium (Fig. S1a, bonline) [6,7].

关 键 词：SYNTHESIS loaded 

分 类 号：R378[医药卫生—病原生物学]