白豆蔻化学成分、药理作用研究进展及其质量标志物的预测分析  

Research advances in chemical components and pharmacological effects of Amomum kravanh and prediction of its Q-markers

作　　者：肖淑华 李字棋 胡国婷 胡鹏翼 郑琴 岳鹏飞 XIAO Shuhua;LI Ziqi;HU Guoting;HU Pengyi;ZHENG Qin;YUE Pengfei(State Key Laboratory of Innovative Drugs&High-Efficiency Energy-Saving&Consumption-Reducing Pharmaceutical Equipment,Key Laboratory of Modern Chinese Pharmaceutical Preparation of Ministry of Education,Jiangxi University of Chinese Medicine,Jiangxi Nanchang 330004,China)

机构地区：[1]江西中医药大学现代中药制剂教育部重点实验室,创新药物与高效节能降耗制药设备国家重点实验室,江西南昌330004

出　　处：《中国医院药学杂志》2024年第21期2548-2556,共9页Chinese Journal of Hospital Pharmacy

基　　金：江西中医药大学重点领域科技创新团队(编号:CXTD22006);江西中医药大学校级研究生创新专项课题(编号:JZYC23S69)。

摘　　要：白豆蔻在中国药用历史悠久,主要含有挥发油类、黄酮类、二芳基庚烷类等化学成分,具有肾脏保护、肝保护、抗肿瘤等药理活性。该文对白豆蔻已报道的化学成分和药理作用进行综述,并结合质量标志物的概念,从植物亲缘学及化学成分特有性、成分与传统药性药效相关性、复方配伍规律、化学成分可测性、不同产地等几个方面对白豆蔻的质量标志物进行预测,初步预测1,8-桉叶素、β-蒎烯、α-蒎烯、α-松油醇、α-律草烯、α-荜澄茄烯和丁香酚可作为白豆蔻的质量标志物,为完善白豆蔻质量标准提供依据。Amomum kravanh has a long history of medicinal use in China.Containing volatile oils,flavonoids,diarylheptane and other chemical components,A.kravanh has pharmacological functions of renohepatic protection and anti-tumor.Here chemical compositions and pharmacological effects of A.kravanh were reviewed and Q-Markers of A.kravanh were predicted from the aspects of plant genealogy,specificity of chemical components,correlation between components,traditional medicinal properties,compound compatibility,chemical composition measurability and different origins.It was preliminarily predicted that 1,8-eucalyptol,β-pinene,α-pinene,α-terpineol,α-caryophyllene,α-cubebene and eugenol could be used as Q-Markers for A.kravanh,providing rationales for optimizing the quality standards of A.kravanh.

关 键 词：白豆蔻 本草考证 化学成分 药理作用 质量标志物 

分 类 号：R282[医药卫生—中药学] R932[医药卫生—中医学]