Biomaterial scaffolds in maxillofacial bone tissue engineering:A review of recent advances  

作　　者：Xiangya Huang Yaxin Lou Yihong Duan He Liu Jun Tian Ya Shen Xi Wei 

机构地区：[1]Hospital of Stomatology,Guanghua School of Stomatology,Sun Yat-Sen University,Guangzhou,China [2]Guangdong Provincial Key Laboratory of Stomatology,Guangzhou,China [3]Division of Endodontics,Department of Oral Biological and Medical Sciences,The University of British Columbi1,Vancouver,British Columbi1,Canada

出　　处：《Bioactive Materials》2024年第3期129-156,共28页生物活性材料（英文）

基　　金：supported by National Natural Science Foundation of China(81970974);Guangdong Financial Fund for High-Caliber Hospital Construction(174-2018-XMZC-0001-03-0125/D-04);National Natural Science Foundation of China(82370943);Key Clinical Technique Program of Guangzhou(2023P-ZD07).

摘　　要：Maxillofacial bone defects caused by congenital malformations,trauma,tumors,and inflammation can severely affect functions and aesthetics of maxillofacial region.Despite certain successful clinical applications of biomaterial scaffolds,ideal bone regeneration remains a challenge in maxillofacial region due to its irregular shape,complex structure,and unique biological functions.Scaffolds that address multiple needs of maxillofacial bone regeneration are under development to optimize bone regeneration capacity,costs,operational convenience.etc.In this review,we first highlight the special considerations of bone regeneration in maxillofacial region and provide an overview of the biomaterial scaffolds for maxillofacial bone regeneration under clinical examination and their efficacy,which provide basis and directions for future scaffold design.Latest advances of these scaffolds are then discussed,as well as future perspectives and challenges.Deepening our understanding of these scaffolds will help foster better innovations to improve the outcome of maxillofacial bone tissue engineering.

关 键 词：Biomaterial scaffolds Maxillofacial region Bone regeneration Tissue engineering 

分 类 号：R318[医药卫生—生物医学工程]