An insect sclerotization-inspired antifouling armor on biomedical devices combats thrombosis and embedding  

作　　者：Nan Lyu Daihua Deng Yuting Xiang Zeyu Du Xiaohui Mou Qing Ma Nan Huang Jing Lu Xin Li Zhilu Yang Wentai Zhang 

机构地区：[1]Dongguan Key Laboratory of Smart Biomaterials and Regenerative Medicine,Department of Cardiology,The Tenth Affiliated Hospital,Southern Medical University,Dongguan,Guangdong,523059,China [2]GuangZhou Nanchuang Mount Everest Company for Medical Science and Technology,Guangzhou,Guangdong,510670,China [3]Department of Anesthesiology,Sichuan Academy of Medical Sciences&Sichuan Provincial People’s Hospital,School of Medicine,University of Electronic Science and Technology of Chin1,Chengdu,Sichuan,610072,China [4]Department of Cardiology,Third People’s Hospital of Chengdu Affiliated to Southwest Jiaotong University,Chengdu,Sichuan,610072,China [5]Guangdong Provincial Key Laboratory of Cardiac Function and Microcirculation,Southern Medical University,Guangzhou,Guangdong,510080,China

出　　处：《Bioactive Materials》2024年第3期562-571,共10页生物活性材料（英文）

基　　金：supported by the National Natural Science Foundation of China,China(Project 82202325,82072072,32171326,32261160372);the Guangdong Basic and Applied Basic Research Foundation,China(2022B1515130010,2021A1515111035);Dongguan Science and Technology of Social Development Program,China(20231800906311,20231800900332);China Postdoctoral Science Foundation,China(2022M721524);Leading Talent Project of Guangzhou Development District,China(2020-L013)。

摘　　要：Thrombus formation and tissue embedding significantly impair the clinical efficacy and retrievability of temporary interventional medical devices.Herein,we report an insect sclerotization-inspired antifouling armor for tailoring temporary interventional devices with durable resistance to protein adsorption and the following protein-mediated complications.By mimicking the phenol-polyamine chemistry assisted by phenol oxidases during sclerotization,we develop a facile one-step method to crosslink bovine serum albumin(BSA)with oxidized hydrocaffeic acid(HCA),resulting in a stable and universal BSA@HCA armor.Furthermore,the surface of the BSA@HCA armor,enriched with carboxyl groups,supports the secondary grafting of polyethylene glycol(PEG),further enhancing both its antifouling performance and durability.The synergy of robustly immobilized BSA and covalently grafted PEG provide potent resistance to the adhesion of proteins,platelets,and vascular cells in vitro.In ex vivo blood circulation experiment,the armored surface reduces thrombus formation by 95%.Moreover,the antifouling armor retained over 60%of its fouling resistance after 28 days of immersion in PBS.Overall,our armor engineering strategy presents a promising solution for enhancing the antifouling properties and clinical performance of temporary interventional medical devices.

关 键 词：ANTIFOULING Temporary interventional devices Insect sclerotization Phenol-polyamine chemistry Universal armor 

分 类 号：O64[理学—物理化学]