Stimuli-responsive peptide assemblies:Design,self-assembly,modulation,and biomedical applications  

作　　者：Rongqiu Mu Danzhu Zhu Sama Abdulmalik Suranji Wijekoon Gang Wei Sangamesh G.Kumbar 

机构地区：[1]College of Chemistry and Chemical Engineering,Qingdao University,266071,Qingdao,China [2]Department of Biomedical Engineering&Department of Materials Science and Engineering,University of Connecticut,Storrs,06269,USA [3]Department of Orthopaedic Surgery,University of Connecticut Health,Farmington,06030,USA

出　　处：《Bioactive Materials》2024年第5期181-207,共27页生物活性材料（英文）

基　　金：support from the National Natural Science Foundation of China(No.51873225);the Taishan Scholars Program of Shandong Province(No.tsqn201909104);the High-Grade Talents Plan of Qingdao University.Dr.Kumbar acknowledges the funding support by the National Institutes of Health(#R01NS134604,#R01EB034202,#R01AR078908,#R01EB030060 and,#R56NS122753);the U.S.Army Medical Research Acquisition Activity(USAMRAA),through the CDMRP Peer-Reviewed Medical Research Program(Award No.W81XWH2010321 and PR230581).

摘　　要：Peptide molecules have design flexibility,self-assembly ability,high biocompatibility,good biodegradability,and easy functionalization,which promote their applications as versatile biomaterials for tissue engineering and biomedicine.In addition,the functionalization of self-assembled peptide nanomaterials with other additive components enhances their stimuli-responsive functions,promoting function-specific applications that induced by both internal and external stimulations.In this review,we demonstrate recent advance in the peptide molecular design,self-assembly,functional tailoring,and biomedical applications of peptide-based nanomaterials.The strategies on the design and synthesis of single,dual,and multiple stimuli-responsive peptide-based nanomaterials with various dimensions are analyzed,and the functional regulation of peptide nanomaterials with active components such as metal/metal oxide,DNA/RNA,polysaccharides,photosensitizers,2D materials,and others are discussed.In addition,the designed peptide-based nanomaterials with temperature-,pH-,ion-,light-,enzyme-,and ROS-responsive abilities for drug delivery,bioimaging,cancer therapy,gene therapy,antibacterial,as well as wound healing and dressing applications are presented and discussed.This comprehensive review provides detailed methodologies and advanced techniques on the synthesis of peptide nanomaterials from molecular biology,materials science,and nanotechnology,which will guide and inspire the molecular level design of peptides with specific and multiple functions for function-specific applications.

关 键 词：Peptide assemblies Molecular design Functional modulation Stimuli-responsive nanomaterials Biomedical applications 

分 类 号：O62[理学—有机化学]