Highly efficient semiconductor modules making controllable parallel microchannels for non-compressible hemorrhages  

作　　者：Fengbo Yang Xiaoli Jia Chao Hua Feifan Zhou Jianing Hua Yuting Ji Peng Zhao Quan Yuan Malcolm Xing Guozhong Lyu 

机构地区：[1]Engineering Research Center of the Ministry of Education for Wound Repair Technology,Jiangnan University,Affiliated Hospital of Jiangnan University,Wuxi,214000,China [2]Wuxi School of Medicine,Jiangnan University,Wuxi,214000,China [3]Medical School of Nantong University,Nantong,226019,China [4]Department of Critical Care Medicine,Affiliated Hospital of Jiangnan University,Wuxi 214000,China [5]Burn&Trauma Treatment Center,Affiliated Hospital of Jiangnan University,Wuxi 214000,China [6]State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical,Research Center for Oral Diseases,West China Hospital of Stomatology,Sichuan University,Chengdu,610041,Sichuan,China [7]Department of Mechanical Engineering,University of Manitoba,Winnipeg,R3T 2N2,Canada

出　　处：《Bioactive Materials》2024年第6期30-47,共18页生物活性材料（英文）

基　　金：the supports from the National Key R&D Program of China(2022YFC3006200);the National Natural Science Foundation of China(82302841);the Jiangsu Provincial Department of Science and Technology(BE2018626).

摘　　要：Nature makes the most beautiful solution to involuted problems.Among them,the parallel tubular structures are capable of transporting fluid quickly in plant trunks and leaf stems,which demonstrate an ingenious evolutionary design.This study develops a mini-thermoelectric semiconductor P-N module to create gradient and parallel channeled hydrogels.The modules decrease quickly the temperature of polymer solution from 20◦C to20◦C within 5 min.In addition to the exceptional liquid absorption rate,the foams exhibited shape memory mechanics.Our mini device universally makes the inspired structure in such as chitosan,gelatin,alginate and polyvinyl alcohol.Non-compressible hemorrhages are the primary cause of death in emergency.The rapid liquid absorption leads to fast activation of coagulation,which provides an efficient strategy for hemostasis management.We demonstrated this by using our semiconductor modules on collagen-kaolin parallel channel foams with their high porosity(96.43%)and rapid expansion rate(2934%).They absorb liquid with 37.25 times of the own weight,show 46.5-fold liquid absorption speed and 24-fold of blood compared with random porous foams.These superior properties lead to strong hemostatic performance in vitro and in vivo.

关 键 词：Parallel microchannel Thermoelectric semiconductors Ice template HEMORRHAGE 

分 类 号：R318[医药卫生—生物医学工程]