A tough,antibacterial and antioxidant hydrogel dressing accelerates wound healing and suppresses hypertrophic scar formation in infected wounds  

作　　者：Xiaoqing Liu Yiming Sun Jie Wang Yongyuan Kang Zhaolong Wang Wangbei Cao Juan Ye Changyou Gao 

机构地区：[1]MOE Key Laboratory of Macromolecular Synthesis and Functionalization,Department of Polymer Science and Engineering,Zhejiang University,Hangzhou,310058,China [2]Eye Center,The Second Affiliated Hospital of Zhejiang University,School of Medicine,Hangzhou,310009,China [3]Center for Healthcare Materials,Shaoxing Institute,Zhejiang University,Shaoxing,312099,China [4]Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering,Taiyuan,030000,China

出　　处：《Bioactive Materials》2024年第4期269-281,共13页生物活性材料（英文）

基　　金：supported by the Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering(2021SZ-TD004);the Natural Science Foundation of Zhejiang Province(LD21E030001);the Joint Fund of National Natural Science Foundation of China(U22A20155);the Lingyan Program of Zhejiang Province(2022C01106).

摘　　要：Wound management is an important issue that places enormous pressure on the physical and mental health of patients,especially in cases of infection,where the increased inflammatory response could lead to severe hypertrophic scars(HSs).In this study,a hydrogel dressing was developed by combining the high strength and toughness,swelling resistance,antibacterial and antioxidant capabilities.The hydrogel matrix was composed of a double network of polyvinyl alcohol(PVA)and agarose with excellent mechanical properties.Hyperbranched polylysine(HBPL),a highly effective antibacterial cationic polymer,and tannic acid(TA),a strong antioxidant molecule,were added to the hydrogel as functional components.Examination of antibacterial and antioxidant properties of the hydrogel confirmed the full play of the efficacy of HBPL and TA.In the in vivo studies of methicillin-resistant Staphylococcus aureus(MRSA)infection,the hydrogel had shown obvious promotion of wound healing,and more profoundly,significant suppression of scar formation.Due to the common raw materials and simple preparation methods,this hydrogel can be mass produced and used for accelerating wound healing while preventing HSs in infected wounds.

关 键 词：Hydrogel dressing Hypertrophic scars Wound healing Bacterial infection ROS-scavenging 

分 类 号：TQ427.26[化学工程] R318.08[医药卫生—生物医学工程]