Extracellular matrix-derived materials for tissue engineering and regenerative medicine:A journey from isolation to characterization and application  

作　　者：Helena Vilaça-Faria Jennifer Noro Rui L.Reis Rogério P.Pirraco 

机构地区：[1]3B’s Research Group,I3Bs-Research Institute on Biomaterials,Biodegradables and Biomimetics,University of Minho,Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine,AvePark,Parque de Ciência e Tecnologia,Zona Industrial da Gandra,4805-017,Barco,Guimarães,Portugal [2]ICVS/3B’s-PT Government Associate Laboratory,Braga,Guimarães,Portugal

出　　处：《Bioactive Materials》2024年第4期494-519,共26页生物活性材料（英文）

基　　金：the EU Horizon 2020 research and innovation programme under the ERC grant CapBed(805411);the contributions to this research from the project“TERM RES Hub-Scientific Infrastructure for Tissue Engineering and Regenerative Medicine”,reference PINFRA/22190/2016(Norte-01-0145-FEDER-022190);funded by the Portuguese National Science Foundation(FCT)in cooperation with the Northern Portugal Regional Coordination and Development Commission(CCDR-N),for providing relevant lab facilities,state-of-the art equipment and highly qualified human resources,the funding for the ICVS/3B’s Associate Laboratory(DOI:10.54499/UIDB/50026/2020,10.54499/UIDP/50026/2020,10.54499/LA/P/0050/2020).

摘　　要：Biomaterial choice is an essential step during the development tissue engineering and regenerative medicine(TERM)applications.The selected biomaterial must present properties allowing the physiological-like recapitulation of several processes that lead to the reestablishment of homeostatic tissue or organ function.Biomaterials derived from the extracellular matrix(ECM)present many such properties and their use in the field has been steadily increasing.Considering this growing importance,it becomes imperative to provide a comprehensive overview of ECM biomaterials,encompassing their sourcing,processing,and integration into TERM applications.This review compiles the main strategies used to isolate and process ECM-derived biomaterials as well as different techniques used for its characterization,namely biochemical and chemical,physical,morphological,and biological.Lastly,some of their applications in the TERM field are explored and discussed.

关 键 词：Extracted ECM Extraction methods CHARACTERIZATION ECM-derived applications 

分 类 号：R318.08[医药卫生—生物医学工程]