氮自由基介导的分子内δ-C(sp^(3))-H胺化的研究进展  

Research Progress in Nitrogen Radical Mediated Intramolecularδ-C(sp^(3))-H Amination

作　　者：张瑞鹤 周爱华[1] Zhang Ruihe;Zhou Aihua(College of Pharmacy,Jiangsu University,Zhenjiang,212013)

机构地区：[1]江苏大学药学院,镇江212013

出　　处：《化学通报》2024年第11期1319-1329,共11页Chemistry

摘　　要：氮自由基通过分子内1,5-氢原子转移(1,5-HAT)可以高效地构建C-N键合成分子内五元氮杂环,并且使用特定催化剂可以较好地控制自由基的手性获得具有立体选择性的化合物。随着科学家们的深入研究,氮自由基的生成条件被不断发展,本文对通过传统化学、电化学、光化学及酶催化途径生成氮自由基进而进行分子内δ-C-H胺化以构建五元氮杂环的相关文献进行了综述,并对部分机理进行了阐述。Nitrogen free radicals can efficiently construct C-N bonds to synthesize intramolecular five-membered nitrogen heterocycles through intramolecular 1,5-hydrogen atom transfer(1,5-HAT),and using specific catalysts can control the chirality of free radicals to obtain stereoselective compounds.With the in-depth research of scientists,the conditions for the formation of nitrogen free radicals have been continuously developed.In this paper,we reviewed the literature on the formation of five-membered nitrogen heterocyclic ring by intramolecularδ-C-H amination mediated by nitrogen free radicals generated through traditional chemical,electrochemical,photochemical and enzyme-catalyzed pathways,and elaborated on some mechanisms.

关 键 词：自由基 1 5-氢原子转移 五元氮杂环 立体选择性 

分 类 号：O621.251[理学—有机化学]