定量CT评估2型糖尿病并发症  

Quantitative CT for assessing complications of type 2 diabetes mellitus

作　　者：陈晓君[1] 刘金 梁晓玲 龚俊 李绍林[1] CHEN Xiaojun;LIU Jin;LIANG Xiaoling;GONG Jun;LI S haolin(Department of Radiology,the Fifth Affiliated Hospital of Sun Yat-Sen University,Zhuhai 519000,China;Department of Spinal Surgery,the Fifth Affiliated Hospital of Sun Yat-Sen University,Zhuhai 519000,China)

机构地区：[1]中山大学附属第五医院放射科,广东珠海519000 [2]中山大学附属第五医院脊柱外科,广东珠海519000

出　　处：《中国介入影像与治疗学》2024年第11期702-707,共6页Chinese Journal of Interventional Imaging and Therapy

摘　　要：目的观察定量CT(QCT)评估2型糖尿病(T2DM)并发症的价值。方法纳入220例T2DM患者并分为无并发症组(n=40)、单一并发症组(n=84)及多并发症组(n=96)。采用QCT技术测量L2~L4骨密度(BMD)、内脏脂肪组织(VAT)与皮下脂肪组织(SAT)面积,并比较组间差异。绘制受试者工作特征曲线,计算曲线下面积(AUC),观察QCT指标及综合模型(临床指标+QCT指标)评估T2DM并发症的价值;采用决策曲线分析(DCA)和临床影响曲线(CIC)分析评价综合模型的临床应用价值。结果3组患者年龄、腰椎BMD、VAT面积差异均有统计学意义(P均<0.05)。综合模型鉴别无并发症组与单一并发症组、无并发症组与多并发症组、单一并发症组与多并发症组的AUC分别为0.753、0.865及0.761,高于单一BMD、VAT及SAT面积(P均<0.05)。DCA及CIC分析显示利用综合模型评估T2DM并发症可获得临床收益,且临床适用性好。结论QCT用于评估T2DM并发症具有较高价值。Objective To explore the value of quantitative CT(QCT)for assessing complications of type 2 diabetes mellitus(T2DM).Methods Totally 220 T2DM patients were included and divided into uncomplicated group(n=40),mono-complicated group(n=84)and multi-complicated group(n=96).Bone mineral density(BMD)of L2—L4,as well as visceral adipose tissue(VAT)and subcutaneous adipose tissue(SAT)area were collected using QCT and compared among groups.The operator characteristic curves were drawn,and the area under the curves(AUC)were calculated to observe the value of QCT indicators and comprehensive model based on clinical indicators and QCT indicators for evaluating complications of T2DM.Decision curve analysis(DCA)and clinical impact curve(CIC)analysis were used to analyze the clinical application value of the comprehensive model.Results Significant differences of patients’age,lumbar BMDs and areas of VAT were found among 3 groups(all P<0.05).The AUC of comprehensive model for differentiating uncomplicated group from mono-complicated group,uncomplicated group from multi-complicated group and mono-complicated group from multi-complicated group was 0.753,0.865,and 0.761,respectively,higher than that of BMD,VAT and SAT area(all P<0.05).DCA and CIC analyses showed that comprehensive model yielded clinical benefits and had good clinical applicability for assessing complications of T2DM.Conclusion QCT was valuable for assessing complications of T2DM.

关 键 词：糖尿病 2型 糖尿病并发症 骨密度 体层摄影术 X线计算机 脂肪定量 

分 类 号：R587.1[医药卫生—内分泌] R814.42[医药卫生—内科学]