2018—2023年国内曼陀罗中毒事件文献分析  

Literature analysis of mandala poisoning incidents in China from 2018 to 2023

作　　者：胡梦涓 吴义刚 潘裕民 乔莉 王一为 HU Mengjuan;WU Yigang;PAN Yumin;QIAO Li;WANG Yiwei(Department of Emergency Medicine,The First Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu 210029,China;不详)

机构地区：[1]南京医科大学第一附属医院急诊医学科,江苏南京210029 [2]南京医科大学第一附属医院质量管理处 [3]青海省海南藏族自治州人民医院院长办公室 [4]南京医科大学康达学院

出　　处：《中国工业医学杂志》2024年第5期491-494,共4页Chinese Journal of Industrial Medicine

基　　金：江苏省医院管理创新研究基金资助项目(JSYGY-3-2023-554)。

摘　　要：检索2018年1月1日至2023年12月31日中国知网期刊全文数据库、万方数据资源、维普中文科技期刊全文数据库、中国生物医学文献服务系统、中华医学期刊全文数据库急性曼陀罗中毒病例报道和回顾性病例相关资料,最终纳入文献38篇,涉及275例患者;所有患者无精神相关疾病史,多数患者无基础疾病;多数患者(69.82%)的中毒原因为误食。临床表现复杂多样,主要包括口干、瞳孔散大、头晕、躁动不安、恶心呕吐、面色潮红、心率快、谵妄等,严重者可出现昏迷、多器官功能衰竭甚至死亡;69.45%的患者在中毒后3 h内出现症状,最长达6 h。主要采取对症治疗,47例患者使用胆碱能拮抗剂,38例患者肌内注射新斯的明,9例予皮下注射毛果芸香碱,122例患者于7 d内出院,6例死亡。对疑似曼陀罗中毒病例,应详细询问病史,并应用毒素检测及物种鉴定方法协助诊断,避免误诊、漏诊。The full-text databases of China National Knowledge Infrastructure(CNKI),Wanfang Data,VIP Chinese Science and Technology Journal,China Biomedical Literature Service System,and Chinese Medical Journal from January 1,2018 to December 31,2023,including reports of acute mandala poisoning cases and retrospective case related information were retrieved by computer.Finally,38 articles were included,involving 275 patients,all patients had no history of mental illness,and most of them had no underlying diseases,majority of poisoned patients(69.82%)caused by ingestion.The clinical manifestations were complex and diverse,mainly including dry mouth,dilated pupils,dizziness,restlessness,nausea and vomiting,flushed complexion,rapid heart rate,delirium,etc.,and coma,multiple organ failure or even death could occur in severe cases;69.45%of the patients experienced symptoms within 3 hours after poisoning with a maximum of 6 hours.The main treatment was symptomatic treatment,with 47 patients received cholinergic antagonists,38 patients received intramuscular injection of neostigmine,and 9 patients received subcutaneous injection of pilocarpine,44.36%of the patients(122 cases)were discharged within 7 days,and 6 patients died.Facing suspected cases the detail medical history and toxin detection were especially important for avoiding misdiagnosis,missed diagnosis.

关 键 词：曼陀罗 急性中毒 抗胆碱能综合征 毒物检测 

分 类 号：R595.3[医药卫生—内科学]