N-钙黏蛋白功能研究进展  

Research Progress in N-cadherin Function

作　　者：陈文灿 周倜[1] CHEN Wencan;ZHOU Ti(Department of Biochemistry and Molecular Biology,Zhongshan School of Medicine,Sun Yat-sen University,Guangzhou 510080,China)

机构地区：[1]中山大学中山医学院生物化学与分子生物学系,广东广州510080

出　　处：《中山大学学报（医学科学版）》2024年第6期866-875,共10页Journal of Sun Yat-Sen University:Medical Sciences

基　　金：国家自然科学基金(82070882);广东省自然科学基金(2023A1515010316,2024A1515012449)。

摘　　要：N-钙黏蛋白(N-cadherin),也称作神经钙黏蛋白(neural-cadherin/Cadherin-2),是一种钙依赖的跨膜糖蛋白,在细胞间粘附、细胞分选、神经发育以及多种生理和病理过程中发挥着关键作用。近年来,随着分子生物学和细胞生物学的快速发展,N-钙黏蛋白的功能研究取得了显著进展,为理解肿瘤转移、神经退行性疾病等提供了重要线索。本文综述了近年来N-钙黏蛋白功能研究的主要进展,包括其分子结构、生物学功能、信号转导机制以及在疾病中的作用,最后总结了N-钙黏蛋白的临床应用前景以及未来研究方向的展望。以期为未来N-cadherin作为新靶点治疗疾病的相关研究和临床应用提供一定的理论参考。N-cadherin,also known as Neural-cadherin/Cadherin-2,is a calcium-dependent transmembrane glycoprotein that plays a crucial role in cell-to-cell adhesion,cell sorting,nerve development and a variety of physiological and pathological processes.In recent years,with the rapid development of molecular biology and cell biology,the functional research of N-cadherin has made remarkable progress,providing essential clues for understanding tumor metastasis and neurodegenerative diseases.In this paper,the main progress in N-cadherin functional research in recent years is reviewed,including its molecular structure,biological function,signal transduction mechanism and its role in diseases.Finally,the clinical application prospect and future research direction of N-cadherin are summarized.It is expected to provide some theoretical reference for future research and clinical application of N-cadherin as a new target for the treatment of diseases.

关 键 词：N-钙黏蛋白 调控与功能 细胞信号转导 发病机制 临床应用 

分 类 号：R3[医药卫生—基础医学]