肿瘤相关巨噬细胞在抗肿瘤免疫治疗中的应用及展望  

Application and Prospect of Tumor-associated Macrophages in Anti-tumor Immunotherapy

作　　者：李雨凝 张乐蒙 LI Yuning;ZHANG Lemeng(Department of Thoracic Medicine,The Affiliated Cancer Hospital of Xiangya School of Medicine,Central South University//Hunan Cancer Hospital,Changsha 410000,China;School of Life and Health Sciences,Hunan University of Science and Technology,Xiangtan 411100,China)

机构地区：[1]中南大学湘雅医学院附属肿瘤医院//湖南省肿瘤医院胸部内一科,湖南长沙410000 [2]湖南科技大学生命科学与健康学院,湖南湘潭411100

出　　处：《中山大学学报（医学科学版）》2024年第6期983-993,共11页Journal of Sun Yat-Sen University:Medical Sciences

基　　金：湖南省科技厅自然科学基金(2023JJ60039,2023JJ40412);湖南省卫生健康委员会课题(B202303027655);长沙市科技局自然科学基金(Kq2208150);吴阶平医学基金(320.6750.2022-22-59)。

摘　　要：抗肿瘤免疫治疗在过去几十年里取得了显著的突破,在某些类型的癌症中展现了前所未有的疗效,但耐药性的出现不仅限制了免疫治疗的长期有效性,还可能导致癌症复发和进展。因此,如何克服免疫治疗耐药,已成为当前癌症研究中亟待解决的关键问题。肿瘤相关巨噬细胞(TAM)近年来已逐渐成为癌症治疗中的一种重要方案和选择,作为潜在的治疗靶点,它们在肿瘤微环境(TME)中的独特作用使其在抗肿瘤治疗中展现出前景。对于癌症治疗中的TAM研究,当前的探索包括多个方面的内容和挑战。这些研究不仅涉及TAM在不同肿瘤类型中的作用机制,还涵盖了TAM在TME中与其他免疫细胞、信号通路的相互作用。因此,本文就TAM在抗肿瘤免疫治疗中的应用进行综述,旨在为未来相关研究提供参考。Anti-tumor immunotherapy has made remarkable breakthroughs in the past few decades,demonstrating unprecedented efficacy in certain types of cancer,but the emergence of drug resistance not only limits the long-term effectiveness of immunotherapy,but can also lead to cancer recurrence and progression.Therefore,how to overcome immunotherapy resistance has become a key problem to be solved in current cancer research.Tumor-associated macrophages(TAM)have gradually become an important option and potential therapeutic target in cancer treatment in recent years.Their unique role in the tumor microenvironment(TME)makes them promising in anti-tumor therapy.For the study of TAM in cancer treatment,the current exploration includes multiple aspects and challenges.These studies not only involved the mechanism of action of TAM in different tumor types,but also covered the interaction of TAM with other immune cells and signaling pathways in TME.Therefore,this article reviews the application of TAM in anti-tumor immunotherapy,aiming to provide reference for future related studies.

关 键 词：肿瘤相关巨噬细胞 肿瘤微环境 免疫治疗 细胞治疗 癌症 

分 类 号：R392.12[医药卫生—免疫学]