肠道微生物在心血管疾病中的作用及机制  

Role of Gut Microbiota in Cardiovascular Diseases and its Mechanism

作　　者：舒妍妍 林旭红 SHU Yanyan;LIN Xuhong(School of Medicine,Henan University,Kaifeng 475000,China;Department of Clinical Laboratory,Huaihe Hospital of Henan University,Kaifeng 475000,China)

机构地区：[1]河南大学医学院,河南开封475000 [2]河南大学淮河医院检验科,河南开封475000

出　　处：《中山大学学报（医学科学版）》2024年第6期994-1005,共12页Journal of Sun Yat-Sen University:Medical Sciences

基　　金：河南省科技厅重点研发与推广专项项目(科技攻关)(192102310045)。

摘　　要：心血管疾病是当前对人体健康造成严重危害的主要疾病,受到了国内外的普遍重视。目前已有的机制研究不足以满足越来越高发的心血管疾病的治疗现状。肠道作为人体最大的微生态系统,和人体之间的相互作用与多种疾病的发病机制有关。近几年,心血管疾病和肠道微生物之间的关系,已被越来越多的人所了解。肠道菌群及其代谢产物水平的改变是促使疾病发生发展的主要因素,对肠道菌群失调进行纠正可能为治疗心血管疾病提供新策略。因此,本文就肠道微生物及其代谢产物在心血管疾病中的应用进行综述,旨在为未来相关研究提供参考。Cardiovascular diseases are now the leading cause of serious harms to human health,have drawn widespread attention both domestically and internationally.But the current research on mechanism of cardiovascular diseases is not keeping up with the current status of their treatment.The microbiota in the gut,the largest microecological system in the human body and its interaction with the human host have been implicated in a variety of diseases.The relationship between gut microbiota and cardiovascular diseases has been increasingly understood in recent years.The changes of gut microbiota and its metabolites are the major contributing factor for the occurrence and development of cardiovascular diseases,therefore,correction of gut microbiota dysbiosis may provide a novel therapeutic alternative for cardiovascular diseases.This article reviews the role of gut microbiota and its metabolites in cardiovascular diseases,aiming to provide reference for future related studies.

关 键 词：肠道微生物 肠道菌群 心血管疾病 肠道通透性 作用机制 治疗 

分 类 号：R541.9[医药卫生—心血管疾病]