惰性键与二氧化碳的电化学羧化反应研究  

Recent Advances in Electrochemical Carboxylation of Inert Chemical Bonds with Carbon Dioxide

作　　者：高小童 钟昱卿 冯楠 孙莹 杨得勇 周锋 Gao Xiaotong;Zhong Yuqing;Feng Nan;Sun Ying;Yang Deyong;Zhou Feng(College of Chemistry and Chemical Engineering,Chongqing University of Science and Technology,Chongqing 401331;Shanghai Key Laboratory of Green Chemistry and Chemical Process,State Key Laboratory of Petroleum Molecular&Process Engineering,School of Chemistry and Molecular Engineering,East China Normal University,Shanghai 200062)

机构地区：[1]重庆科技大学化学化工学院,重庆401331 [2]华东师范大学化学与分子工程学院石油化工分子转化与反应工程全国重点实验室、上海市绿色化学与化工过程绿色化重点实验室,上海200062

出　　处：《有机化学》2024年第10期3043-3062,共20页Chinese Journal of Organic Chemistry

基　　金：国家重点研发计划(No.2020YFA0710200);国家自然科学基金(No.22171090);中央高校基本科研业务费专项资金;重庆市自然科学基金(No.CSTB-2022NSCQ-MSX0388)资助项目

摘　　要：二氧化碳(CO_(2))是一种绿色可再生的C1合成子,通过与惰性键的羧化反应,能够实现从简单分子到高附加值羧酸衍生物的直接转化,兼具步骤经济性与原子经济性.有机电合成是利用电子作“试剂”的绿色合成技术,发展电化学促进的惰性键与二氧化碳的羧化反应成为近年研究热点.按照C—H、C—C、C—O、C—F键的分类,综述了二氧化碳参与惰性键的电还原羧化反应的研究成果,着重讨论了反应机理及应用,并对该领域发展趋势进行了展望.Carbon dioxide(CO_(2))is a green and renewable C1 synthon,and the direct carboxylation of inert chemical bonds with CO_(2)could afford high value-added carboxylic acid derivatives from simple molecules,which feature both atomic and step economies.Organic electrosynthesis is a green synthesis technology using electrons as"reagents",and the development of electrochemical carboxylation of inert bonds with CO_(2) has become a hot research topic in recent years.The recent progress on the electroreductive carboxylation of inert bonds with CO_(2) is summarized,including C—H,C—C,C—O,and C—F single bonds.The mechanism and application of these reactions are emphatically discussed,and the challenges and development trends in this field are also covered.

关 键 词：二氧化碳 惰性键 电化学 还原羧化 羧酸 

分 类 号：O621.259.2[理学—有机化学]