Advances in Dearomative Carboxylation of Aromatic Compounds with Carbon Dioxide  

二氧化碳参与的芳香化合物去芳构化羧化反应研究进展

作　　者：Li Jiayuan Yi Yaping Xi Chanjuan 李嘉元;易雅平;席婵娟(清华大学化学系生命有机磷化学及化学生物学教育部重点实验室,北京100084;南开大学元素有机化学国家重点实验室,天津300071)

机构地区：[1]MOE Key Laboratory of Bioorganic Phosphorus Chemistry&Chemical Biology,Department of Chemistry,Tsinghua University,Beijing 100084 [2]State Key Laboratory of Elemento-organic Chemistry,Nankai University,Tianjin 300071

出　　处：《有机化学》2024年第10期3136-3146,共11页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(Nos.22071134,22371159)资助项目。

摘　　要：Dearomative carboxylation of aromatic compounds with carbon dioxide(CO_(2))could be utilized for the synthesis of cyclic carboxylative frameworks.The dearomative carboxylation exhibits advantages such as reconstitution molecular spatial structure,environmental friendliness,mild conditions,high yield,and high selectivity,and is of significant importance in pharmaceutical synthesis and natural product chemistry.The recent advancements in the dearomative carboxylation of aromatics with CO_(2) are summarized,including elucidation of the reaction characteristics and the scope of substrates via transition-metal catalysis,photoredox catalysis,and electropromoted chemistry.二氧化碳(CO_(2))参与的芳香化合物去芳构化羧化反应可用于合成具有环状分子骨架的羧酸类分子.去芳构化羧化反应具有分子结构重构、环境友好、条件温和、产率高、选择性高等优点,在药物合成和天然产物合成化学中具有重要意义.综述了近年来二氧化碳参与的芳香化合物去芳构化羧化反应的研究,包括过渡金属催化、光氧化还原催化和电促进化学等反应体系的反应特点和底物范围.

关 键 词：dearomative carboxylation aromatic compound carbon dioxide metal catalysis PHOTOCATALYSIS electropromoted chemistry 

分 类 号：O621.25[理学—有机化学]