非均相催化氢甲酰化的串联反应研究进展  

Progress in Heterogeneous Catalyzed Tandem Reactions Based on Hydroformylation

作　　者：周宇飞 贾肖飞 Zhou Yufei;Ji Xiaofei(Shandong Key Laboratory of Biochemical Analysis,College of Chemistry and Molecular Engineering,Qingdao University of Science and Technology,Qingdao,Shandong 266042)

机构地区：[1]青岛科技大学化学与分子工程学院、山东省生化分析重点实验室,山东青岛266042

出　　处：《有机化学》2024年第10期3147-3158,共12页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.21703116)资助项目.

摘　　要：氢甲酰化反应是工业上合成醛的重要方法之一.醛进一步通过有机反应转化为缩醛、醇、胺和羧酸等多种精细化学品.随着绿色化学的发展,非均相催化剂由于分离和循环使用等优势而引起广泛的关注.另外,基于氢甲酰化的串联反应能够“一锅法”得到醛的衍生物,不需要分离中间体醛,减少反应步骤和能量消耗,进而有效地提高了催化效率.因此,结合非均相催化和串联反应的理念,发展非均相的氢甲酰化串联反应催化剂具有重要的研究价值.此综述总结了非均相氢甲酰化-缩醛化、氢甲酰化-氢化、氢胺甲基化和氢甲酰化-Aldol四类串联反应的研究进展,介绍了催化剂的合成及应用.最后,对催化剂的发展和反应方向进了展望.Hydroformylation is one of the most important methods to synthesize aldehydes in industry.Aldehydes are converted into various fine chemicals such as acetals,alcohols,amines and carboxylic acids by further organic reactions.With the development of green chemistry,heterogeneous catalysts have attracted wide attention due to their advantages of easy separation and recycling.In addition,the tandem reaction based on hydroformylation can afford aldehyde derivatives by one-pot method reaction,without separating the intermediate aldehyde products,reducing the reaction steps and energy consumption,and effectively improving the catalytic efficiency.Therefore,combining the concept of heterogeneous catalysis and tandem reaction,the development of heterogeneous catalyst for hydroformylation related tandem reaction has important research value.The research progress of heterogeneous tandem hydroformylation-acetalization,hydroformylation-hydrogenation,hydroaminomethylation and hydroformylation-aldol is summarized,including the synthesis and application of catalysts.Finally,development of catalyst and tandem reaction are prospected.

关 键 词：非均相催化剂 氢甲酰化-缩醛化 氢甲酰化-氢化 氢胺甲基化 氢甲酰化-Aldol 

分 类 号：O621.251[理学—有机化学]