钯催化的三取代烯烃钯催化的三取代烯烃的对映和非对映选择性氢羧基化反应  

Pd-Catalyzed Enantio-and Diastereo-selective Hydrocarboxylation of Trisubstituted Alkenes

作　　者：王震 董开武 Wang Zhen;Dong Kaiwu(Shanghai Key Laboratory of Green Chemistry and Chemical Processes,Chang-Kung Chuang Institute,School of Chemistry and Molecular Engineering,East China Normal University,Shanghai 200062)

机构地区：[1]华东师范大学化学与分子工程学院、庄长恭研究所、上海市绿色化学与化工过程绿色化重点实验室,上海200062

出　　处：《有机化学》2024年第10期3249-3257,共9页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.22271094)资助项目.

摘　　要：报道了一种钯催化三取代烯烃的不对称分子间氢羧基化反应,以中等到优秀的产率、对映选择性以及优异的非对映选择性得到了一系列含有两个手性中心的琥珀酸衍生物.所得手性丁二酸酯类化合物通过简单的衍生化即可制备高光学纯度的γ-丁内酯类化合物,彰显了该催化方法在有机合成中的潜在应用.A palladium-catalyzed asymmetric intermolecular hydrocarboxylation of trisubstituted alkenes was reported,which afforded a series of succinic acid derivatives containing two chiral centers with moderate to excellent yields,enantioselectivity,and high diastereoselectivity.The resulting dimethyl succinates can be easily converted to optically activeγ-butyrolactones,demonstrating the potential application of this method.

关 键 词：钯 不对称 氢羰基化 烯烃 琥珀酸 一氧化碳 

分 类 号：O621.251[理学—有机化学]