Odor representation and coding by the mitral/tufted cells in the olfactory bulb  

作　　者：Panke WANG Shan LI An’an LI 

机构地区：[1]School of Biomedical Engineering,Guangdong Medical University,Dongguan 523808,China [2]Jiangsu Key Laboratory of Brain Disease and Bioinformation,Research Center for Biochemistry and Molecular Biology,Xuzhou Medical University,Xuzhou 221002,China

出　　处：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2024年第10期824-840,共17页浙江大学学报（英文版）B辑（生物医学与生物技术）

基　　金：supported by the National Natural Science Foundation of China(Nos.32271055 and 32070995);the Jiangsu Province Innovative and Entrepreneurial Team Program,and the Guangdong Medical University(No.GDMUB2022048),China.

摘　　要：The olfactory bulb(OB)is the first relay station in the olfactory system and functions as a crucial hub.It can represent odor information precisely and accurately in an ever-changing environment.As the only output neurons in the OB,mitral/tufted cells encode information such as odor identity and concentration.Recently,the neural strategies and mechanisms underlying odor representation and encoding in the OB have been investigated extensively.Here we review the main progress on this topic.We first review the neurons and circuits involved in odor representation,including the different cell types in the OB and the neural circuits within and beyond the OB.We will then discuss how two different coding strategies—spatial coding and temporal coding—work in the rodent OB.Finally,we discuss potential future directions for this research topic.Overall,this review provides a comprehensive description of our current understanding of how odor information is represented and encoded by mitral/tufted cells in the OB.

关 键 词：Olfactory bulb Mitral/tufted cells Odor identity Neural representation Information encoding 

分 类 号：R318[医药卫生—生物医学工程] Q81[医药卫生—基础医学]