Neural substrates for regulating self-grooming behavior in rodents  

作　　者：Guanqing LI Chanyi LU Miaomiao YIN Peng WANG Pengbo ZHANG Jialiang WU Wenqiang WANG Ding WANG Mengyue WANG Jiahan LIU Xinghan LIN Jian-Xu ZHANG Zhenshan WANG Yiqun YU Yun-Feng ZHANG 

机构地区：[1]State Key Laboratory of Integrated Management of Pest Insects and Rodents,Institute of Zoology,Chinese Academy of Sciences,Beijing 100101,China [2]CAS Center for Excellence in Biotic Interactions,University of Chinese Academy of Sciences,Beijing 100101,China [3]School of Life Sciences,Hebei University,Baoding 071002,China [4]State Key Laboratory of Molecular Development Biology,Institute of Genetics and Developmental Biology,Chinese Academy of Sciences,Beijing 100101,China [5]Department of Rehabilitation Medicine,Tianjin Huanhu Hospital,Tianjin 300350,China [6]Medical Center for Human Reproduction,Beijing Chao-Yang Hospital,Capital Medical University,Beijing 100101,China [7]Department of Gastrointestinal Surgery,the People’s Hospital of Zhaoyuan City,Zhaoyuan 265400,China [8]School of Life Sciences,Division of Life Sciences and Medicine,University of Science and Technology of China,Hefei 230026,China [9]Department of Otolaryngology,Eye,Ear,Nose&Throat Hospital,Fudan University,Shanghai 200031,China [10]Ear,Nose&Throat Institute,Eye,Ear,Nose&Throat Hospital,Fudan University,Shanghai 200031,China [11]Clinical and Research Center for Olfactory Disorders,Eye,Ear,Nose&Throat Hospital,Fudan University,Shanghai 200031,China

出　　处：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2024年第10期841-856,共16页浙江大学学报（英文版）B辑（生物医学与生物技术）

基　　金：supported by the National Natural Science Foundation of China(No.82371515);the Talent Initiation BaiRen Plan Start-up Funds(No.E251F811);the State Key Laboratory of Integrated Management of Pest Insects and Rodents(No.IPM2301),China.

摘　　要：Grooming,as an evolutionarily conserved repetitive behavior,is common in various animals,including humans,and serves essential functions including,but not limited to,hygiene maintenance,thermoregulation,de-arousal,stress reduction,and social behaviors.In rodents,grooming involves a patterned and sequenced structure,known as the syntactic chain with four phases that comprise repeated stereotyped movements happening in a cephalocaudal progression style,beginning from the nose to the face,to the head,and finally ending with body licking.The context-dependent occurrence of grooming behavior indicates its adaptive significance.This review briefly summarizes the neural substrates responsible for rodent grooming behavior and explores its relevance in rodent models of neuropsychiatric disorders and neurodegenerative diseases with aberrant grooming phenotypes.We further emphasize the utility of rodent grooming as a reliable measure of repetitive behavior in neuropsychiatric models,holding promise for translational psychiatry.Herein,we mainly focus on rodent self-grooming.Allogrooming(grooming being applied on one animal by its conspecifics via licking or carefully nibbling)and heterogrooming(a form of grooming behavior directing towards another animal,which occurs in other contexts,such as maternal,sexual,aggressive,or social behaviors)are not covered due to space constraints.

关 键 词：GROOMING Repetitive behavior Syntactic chain Cephalocaudal progression Neuropsychiatric disorders 

分 类 号：Q81[生物学—生物工程]