幽门螺杆菌分型对消化性溃疡治疗后生物标志物的影响  

Effect of H.pylori subtyping on biomarkers after peptic ulcer treatment

作　　者：严思佳 YAN Sijia(The First People's Hospital of Chun'an County,Zhejiang 311700,China)

机构地区：[1]浙江省淳安县第一人民医院,淳安311700

出　　处：《浙江创伤外科》2024年第11期2030-2033,共4页Zhejiang Journal of Traumatic Surgery

基　　金：浙江省医药卫生科技计划项目(2022KY1073)。

摘　　要：目的探究不同幽门螺杆菌(HP)分型对消化性溃疡患者根除治疗后生物标志物如CD4^(+)T细胞、Ⅰ型原胶原N端前肽(PINP)、白介素-10(IL-10)及IL-17水平的影响。方法研究开展时间为2020年3月至2023年4月,选取69例进行HP根除治疗的消化性溃疡患者,根据HP分型检测进行分组:HPⅠ型组(n=39),HPⅡ型组(n=30),另选取同期收治的HP阴性的消化性溃疡患者51例作为HP阴性组,进行常规治疗。比较治疗效果、组间治疗前后CD4^(+)T细胞、PINP及炎症因子水平差异。结果三组治疗后的CD4^(+)T细胞水平、PINP及炎症因子水平均较治疗前降低,且治疗前、治疗后HPⅡ型组患者的CD4^(+)T细胞水平、PINP、TNF-α、IL-10及IL-17水平高于HP阴性组,HPⅠ型组高于HPⅡ型组(P<0.05)。结论不同分型HP感染消化性溃疡患者根除治疗后的临床疗效无明显差异,但HPⅠ型患者的CD4^(+)T细胞、PINP及炎症因子水平在治疗后仍高于HPⅡ型组和HP阴性患者。Objective To explore the effects of different H.pylori(HP)types on post-eradication biomarkers such as CD4^(+)T cells,collagen I N terminal propeptide(PINP),interleukin-10(IL-10),and IL-17 in patients with peptic ulcer.Methods The study was conducted from March 2020 to April 2023,involving 69 patients with peptic ulcers undergoing HP eradication therapy.Based on HP typing,patients were divided into:HP typeⅠgroup(n=39),HP typeⅡgroup(n=30),and an HP-negative group(n=51)treated concurrently,which received standard treatment.Treatment outcomes and differences in levels of CD4^(+)T cells,PINP,and inflammatory markers before and after treatment were compared among the groups.Results After treatment,the levels of CD4^(+)T cells,PINP,and inflammatory markers decreased in all groups.Before and after treatment,the levels of CD4^(+)T cells,PINP,TNF-α,IL-10,and IL-17 in the HP typeⅡgroup were higher than those in the HP-negative group,with the HP typeⅠgroup showing higher levels than the HP typeⅡgroup(P<0.05).Conclusion HP classification has a significant effect on the immune response and inflammatory factor levels in peptic ulcer patients after eradication treatment,and CD4^(+)T cells,PINP and inflammatory factors were significantly higher in HP-positive patients,and the HPⅠgroup was higher than the HPⅡgroup.

关 键 词：幽门螺杆菌 消化性溃疡 CD4+T细胞 Ⅰ型原胶原N端前肽 白介素-10 白介素-17 

分 类 号：R656.6[医药卫生—外科学]