前列腺癌组织LncRNA NEAT1、miR-377表达与患者5年生存情况的关系  

The relationship between the expression of long non-coding RNA nucleus enriched abundant transcript 1 and microRNA-377 in prostate cancer tissue and the 5-year survival of patients

作　　者：韩坤岭[1] 平玉杰[1] 李博科 霍仲超 王俊红 李慧敏[1] 任丽萍 HAN Kunling;PING Yujie;LI Boke;HUO Zhongchao;WANG Junhong;LI Huimin;REN Liping(Department of Urology and Surgery,Handan Central Hospital,Handan 056000,Hebei,China)

机构地区：[1]邯郸市中心医院泌尿外一科,河北邯郸056000

出　　处：《中国性科学》2024年第11期27-31,共5页Chinese Journal of Human Sexuality

基　　金：河北省医学科学研究课题计划项目(20200459)。

摘　　要：目的探究前列腺癌组织长链非编码RNA核富集转录本1(LncRNA NEAT1)、微小RNA-377(miR-377)表达与患者5年生存的关系。方法选取2016年7月至2018年8月在邯郸市中心医院住院治疗的98例前列腺癌患者,检测前列腺癌组织及癌旁组织中LncRNA NEAT1、miR-377表达;记录患者5年内生存情况。分析前列腺癌组织LncRNA NEAT1、miR-377与临床病理特征、患者5年生存的关系以及二者的相关性,分析影响患者5年内生存的危险因素及LncRNA NEAT1、miR-377对患者5年内生存的预测价值。结果与癌旁组织比较,前列腺癌组织LncRNA NEAT1显著升高、miR-377显著降低(P<0.05);Ⅲ~Ⅳ期、Gleason评分>7分、血清前列腺特异性抗原(PSA)>10μg/L的患者前列腺癌组织LncRNA NEAT1分别高于Ⅰ~Ⅱ期、Gleason评分≤7分、血清PSA≤10μg/L的患者,miR-377分别低于Ⅰ~Ⅱ期、Gleason评分≤7分、血清PSA≤10μg/L的患者(P<0.05);前列腺癌组织LncRNA NEAT1与miR-377表达呈负相关(P<0.05);LncRNA NEAT1高表达、miR-377低表达患者5年累积生存率分别显著低于LncRNA NEAT1低表达、miR-377高表达患者(P<0.05);与生存组比较,死亡组前列腺癌组织LncRNA NEAT1显著升高,miR-377显著降低(P<0.05);前列腺癌组织LncRNA NEAT1高表达、miR-377低表达、TNM分期Ⅲ~Ⅳ期、Gleason评分>7分、血清PSA水平>10μg/L均是影响前列腺癌患者5年内生存的独立危险因素(P<0.05);前列腺癌组织LncRNA NEAT1和miR-377二者联合预测患者5年内生存的曲线下面积高于LncRNA NEAT1、miR-377各自单独预测(P<0.05)。结论前列腺癌组织LncRNA NEAT1呈高表达、miR-377呈低表达,对患者5年内生存具有较高的预测价值。Objective To investigate the relationship between the expression of long non-coding RNA nucleus enriched abundant transcript 1(LncRNA NEAT1)and microRNA-377(miR-377)in prostate cancer tissues and the 5-year survival of patients.Methods A total of 98 patients with prostate cancer who were hospitalized in Handan Central Hospital from July 2016 to August 2018 were selected.The expression of LncRNA NEAT1 and miR-377 in prostate cancer tissues and para-carcinoma tissues were detected,and the survival of patients within 5 years was recorded.The relationship between LncRNA NEAT1 and miR-377 in prostate cancer tissue and the clinical pathological characteristics and 5-year survival of patients,as well as the correlation between the two were analyzed.The risk factors influencing the 5-year survival of patients and the predictive value of LncRNA NEAT1 and miR-377 for the 5-year survival of patients were analyzed.Results Compared with the para-carcinoma tissues,LncRNA NEAT1 in prostate cancer tissue was significantly increased,while miR-377 was significantly decreased(P<0.05).LncRNA NEAT1 in prostate cancer tissues of patients with stageⅢtoⅣ,Gleason score>7 points and serum prostate specific antigen(PSA)>10μg/L were higher than those of patients with stageⅠtoⅡ,Gleason score≤7 points and serum PSA≤10μg/L respectively;while miR-377 was lower than that of stageⅠtoⅡpatients,Gleason score≤7 points,serum PSA≤10μg/L,respectively(P<0.05).The expression of LncRNA NEAT1 and miR-377 in prostate cancer tissue was negatively correlated(P<0.05).The 5-year cumulative survival rate of patients with high expression of LncRNA NEAT1 and low expression of miR-377 was significantly lower than that of patients with low expression of LncRNA NEAT1 and high expression of miR-377,respectively(P<0.05).Compared with the survival group,LncRNA NEAT1 in prostate cancer tissue of the death group was significantly increased,while miR-377 was significantly decreased(P<0.05).High LncRNA NEAT1 expression,low miR-377 expression,TNM stage

关 键 词：前列腺癌 长链非编码RNA核富集转录本1 微小RNA-377 5年生存 危险因素 

分 类 号：R691[医药卫生—泌尿科学]