老年良性前列腺增生患者血清Hcy、HbA1c、sdLDL-C水平与下尿路症状严重程度的相关性分析  

Correlation analysis between serum homocysteine,glycosylated hemoglobin,small and dense low-density lipoprotein cholesterol levels and severity of lower urinary tract symptoms in elderly patients with benign prostatic hyperplasia

作　　者：冯艳霞 岳燕军 张宏燕 宁建峰 FENG Yanxia;YUE Yanjun;ZHANG Hongyan;NING Jianfeng(Department of Laboratory Medicine,Zhangjiakou First Hospital,Zhangjiakou 075000,Hebei,China)

机构地区：[1]张家口市第一医院检验医学科,河北张家口075000

出　　处：《中国性科学》2024年第11期45-48,共4页Chinese Journal of Human Sexuality

基　　金：国家重点研发计划“主动健康和老龄化科技应对”重点专项子课题项目(2021YFC2009300)。

摘　　要：目的分析老年良性前列腺增生(BPH)患者血清同型半胱氨酸(Hcy)、糖化血红蛋白(HbA1c)、小而密低密度脂蛋白胆固醇(sdLDL-C)水平与下尿路症状严重程度的相关性。方法选取2020年4月至2022年7月张家口市第一医院收治的106例老年BPH患者作为研究对象,设为患病组。根据下尿路症状严重程度分为重度组(n=23)、中度组(n=46)、轻度组(n=37)。另选取同期进行体检的106例老年健康者设为对照组。采用酶联免疫吸附试验法检测血清Hcy、sdLDL-C水平,采用高效液相色谱法检测HbA1c水平;采用Spearman法分析重度组血清Hcy、HbA1c、sdLDL-C水平与国际前列腺症状评分(IPSS)的相关性;采用受试者工作特征(ROC)曲线分析血清Hcy、HbA1c、sdLDL-C水平诊断老年BPH患者发生重度下尿路症状的临床价值。结果与对照组比较,患病组前列腺体积显著增大,最大尿流率显著降低(P<0.05);患病组血清Hcy、HbA1c、sdLDL-C水平均显著高于对照组(P<0.05);血清Hcy、HbA1c、sdLDL-C水平及IPSS随着下尿路症状严重程度增加呈逐渐升高趋势(P<0.05);重度组血清Hcy、HbA1c、sdLDL-C水平与IPSS均呈正相关(P<0.05);血清Hcy、HbA1c、sdLDL-C诊断老年BPH患者发生重度下尿路症状的曲线下面积(AUC)分别为0.773、0.699、0.679,三者联合诊断的AUC为0.850,三者联合诊断优于单独诊断(P<0.05)。结论老年BPH患者血清Hcy、HbA1c、sdLDL-C水平上调,且随下尿路症状严重程度增加呈逐渐升高趋势,三者联合诊断老年BPH患者发生重度下尿路症状具有较高的临床价值。Objective To analyze the correlation between serum homocysteine(Hcy),glycosylated hemoglobin(HbA1 c),small and dense low-density lipoprotein cholesterol(sdLDL-C)levels and the severity of lower urinary tract symptoms in elderly patients with benign prostatic hyperplasia(BPH).Methods A total of 106 elderly patients with BPH admitted to Zhangjiakou First Hospital from April 2020 to July 2022 were collected as the research subjects and set as disease group.According to the severity of lower urinary tract symptoms,they were separated into severe group(n=23),moderate group(n=46),and mild group(n=37).Another 106 elderly healthy individuals who came for physical examination were selected and set as the control group.Enzyme linked immunosorbent assay was applied to detect serum Hcy and sdLDL-C levels,high performance liquid chromatography was applied to detect HbA1 c level;Spearman method was applied to analyze the correlation between serum Hcy,HbA1 c,sdLDL-C levels and the international prostate symptom scale(IPSS)in severe group;receiver operating characteristic(ROC)curve was applied to analyze the diagnostic value of serum Hcy,HbA1 c,and sdLDL-C levels for diagnosing severe lower urinary tract symptoms in elderly patients with BPH.Results Compared with the control group,the prostate volume of the diseased group significantly increased and the maximum urine flow rate significantly decreased(P<0.05);the levels of serum Hcy,HbA1 c,and sdLDL-C in the disease group were significantly higher than those in the control group(P<0.05);the levels of serum Hcy,HbA1 c,sdLDL-C,and IPSS gradually increased with the severity of lower urinary tract symptoms(P<0.05);there was a positive correlation between serum Hcy,HbA1 c,sdLDL-C,and IPSS in the severe group(P<0.05);the area under the curve(AUC)of serum Hcy,HbA1 c,and sdLDL-C in the diagnosis of severe lower urinary tract symptoms in elderly patients with BPH was 0.773,0.699,and 0.679,respectively,the AUC of the combined diagnosis of the three was 0.850,and the combination of the thre

关 键 词：老年良性前列腺增生 同型半胱氨酸 糖化血红蛋白 小而密低密度脂蛋白胆固醇 下尿路症状严重程度 

分 类 号：R697[医药卫生—泌尿科学]