抗氧化剂在卵巢储备功能减退患者中的研究进展  

Research progress of antioxidants in patients with diminished ovarian reserve

作　　者：王佳雪 相珊 鞠文涵 连方[2] WANG Jiaxue;XIANG Shan;JU Wenhan;LIAN Fang(Master Degree Candidate of Gynecology of Chinese Medicine Enrolled in 2023,the First School of Clinical Medicine,Shandong University of Chinese Medicine,Jinan 250013,Shandong,China;Department of Integrated Chinese and Western Medicine for Reproductive and Genetic Health,the Affiliated Hospital of Shandong University of Chinese Medicine,Jinan 250014,Shandong,China;Master Degree Candidate of Gynecology of Chinese Medicine Enrolled in 2021,the First School of Clinical Medicine,Shandong University of Chinese Medicine,Jinan 250013,Shandong,China)

机构地区：[1]山东中医药大学第一临床医学院,济南250013 [2]山东中医药大学附属医院中西医结合生殖与遗传中心,济南250014

出　　处：《中国性科学》2024年第11期49-52,共4页Chinese Journal of Human Sexuality

基　　金：国家自然科学基金面上项目(82174429)。

摘　　要：卵巢储备功能减退(DOR)患者的生育能力会受到影响,铁死亡、自身免疫、基因不稳定、环境有害物质、端粒缩短等均为诱导DOR的因素。氧化与抗氧化失衡可导致氧化应激(OS),OS会影响女性的生殖寿命。抗氧化剂可控制细胞氧化还原并影响转录活性,对重塑氧化还原平衡、提高女性生殖能力具有重要作用。本文综述抗氧化剂在DOR患者中的治疗作用及其作用机制,以期为DOR治疗提供新思路。Fertility is affected in patients with diminished ovarian reserve(DOR).Ferroptosis,autoimmunity,genetic instability,environmental harmful substances,and telomere shortening are all factors that contribute to the induction of DOR.The imbalance between oxidation and antioxidation can lead to oxidative stress(OS),which affects female reproductive lifespan.Antioxidants can control cellular redox and affect transcriptional activity,which is of great significance in reshaping redox balance and improving female reproductive capacity.This article reviews the therapeutic effects and mechanisms of antioxidants in patients with DOR,aiming to provide new insights for DOR treatment.

关 键 词：卵巢储备功能减退 氧化应激 抗氧化剂 

分 类 号：R711[医药卫生—妇产科学]