子痫前期患者血清MDA、TMAO、PLGF的水平变化及诊断价值  

The changes and diagnostic value of serum malondialdehyde,trimethylamine N-oxide,and placental growth factor levels in patients with preeclampsia

作　　者：宋丽丽[1] 王文君 甄慧 SONG Lili;WANG Wenjun;ZHEN Hui(Department of Obstetrics,Tangshan Maternal and Child Health Hospital,Tangshan 063000,Hebei,China)

机构地区：[1]唐山市妇幼保健院产科,河北唐山063000

出　　处：《中国性科学》2024年第11期95-99,共5页Chinese Journal of Human Sexuality

摘　　要：目的探讨子痫前期患者血清丙二醛(MDA)、氧化三甲胺(TMAO)、胎盘生长因子(PLGF)的水平变化及诊断价值。方法选取2020年10月至2022年10月唐山市妇幼保健院收治的75例子痫前期患者作为研究组,选取同期体检的75例健康孕妇作为对照组。采用酶联免疫吸附试验法检测两组血清MDA、TMAO、PLGF水平,根据病情程度将子痫前期患者分为轻度子痫前期组(n=50)和重度子痫前期组(n=25)。比较对照组和研究组、轻度子痫前期组和重度子痫前期组血清MDA、TMAO、PLGF水平,采用Logistic回归分析子痫前期病情严重程度的影响因素,采用受试者工作特征(ROC)曲线分析血清MDA、TMAO、PLGF水平对子痫前期的诊断价值。结果研究组收缩压、舒张压、24 h尿蛋白水平均高于对照组(P<0.05)。研究组血清MDA、TMAO水平均高于对照组,血清PLGF水平低于对照组(P<0.05)。重度子痫前期组血清MDA、TMAO水平均高于轻度子痫前期组,血清PLGF水平低于轻度子痫前期组(P<0.05)。Logistic回归分析结果显示,MDA、TMAO是子痫前期重度的危险因素(P<0.05),PLGF是子痫前期重度的保护因素(P<0.05)。血清MDA、TMAO、PLGF三者联合诊断效能高于各指标单独诊断(P<0.05)。结论子痫前期患者血清MDA、TMAO水平显著升高,PLGF水平显著降低,三者联合诊断效能高于各指标单独诊断。Objective To explore the changes and diagnostic value of serum malondialdehyde(MDA),trimethylamine N-oxide(TMAO)and placental growth factor(PLGF)levels in patients with preeclampsia.Methods A total of 75 patients with preeclampsia admitted to Tangshan Maternal and Child Health Hospital from October 2020 to October 2022 were collected as the study group,and 75 healthy pregnant women who came to the same hospital during the same period for physical examination were collected as the control group.Enzyme linked immunosorbent assay was applied to detect the levels of serum MDA,TMAO,and PLGF in the two groups.According to the severity of the condition,patients with preeclampsia were separated into a mild preeclampsia group(n=50)and a severe preeclampsia group(n=25).Logistic regression analysis was used to analyze the influencing factors of the severity of preeclampsia.Receiver operating characteristic(ROC)curve was applied to analyze the diagnostic value of serum MDA,TMAO,and PLGF levels for preeclampsia.Results The systolic blood pressure,diastolic blood pressure,and 24-h urine protein levels in the study group were all higher than those in the control group(P<0.05).The serum MDA and TMAO levels in the study group were both higher than those in the control group,and the serum PLGF level were lower than that in the control group(P<0.05).The serum MDA and TMAO levels in the severe preeclampsia group were higher than those in the mild preeclampsia group,and the serum PLGF level was lower than that in the mild preeclampsia group(P<0.05).The results of Logistic regression analysis showed that,MDA and TMAO were risk factors for severe preeclampsia(P<0.05),while PLGF was a protective factor for severe preeclampsia(P<0.05).The combined diagnostic efficacy of serum MDA,TMAO,and PLGF was higher than that of each indicator alone(P<0.05).Conclusions Serum MDA and TMAO levels were significantly increased and PLGF levels were significantly decreased in patients with preeclampsia,and the combined diagnostic efficacy of the three ind

关 键 词：子痫前期 丙二醛 氧化三甲胺 胎盘生长因子 诊断 

分 类 号：R711[医药卫生—妇产科学]