经典名方葶苈大枣泻肺汤关键信息考证与古今应用分析  

A Review of Classic Formula Tingli Dazao Xiefeitang:Key Information Exploration and Ancient and Modern Applications

作　　者：孔亚敏 梁绿圆 曹佳蕾 王选 陈丽源 魏炳琦 常雨洁 李懿涵 席乐迎 马丙祥[1,2] 史文丽[1,2] KONG Yamin;LIANG Lyuyuan;CAO Jialei;WANG Xuan;CHEN Liyuan;WEI Bingqi;CHANG Yujie;LI Yihan;XI Leying;MA Bingxiang;SHI Wenli(Pediatric Hospital of The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou450099,China;Pediatric Medical College,Henan University of Chinese Medicine,Zhengzhou 450046,China;Zhengzhou Shizhuo Pharmaceutical Technology Co.Ltd.,Zhengzhou 450046,China;Henan Liang Jishi Research Institute of Chinese Medicine,Zhengzhou 450046,China;Traditional Chinese Medicine School,Henan University of Chinese Medicine,Zhengzhou 450046,China)

机构地区：[1]河南中医药大学第一附属医院儿科医院,郑州450099 [2]河南中医药大学儿科医学院,郑州450046 [3]郑州世卓医药科技有限公司,郑州450046 [4]河南梁济时中医药科技研究院,郑州450046 [5]河南中医药大学中医学院,郑州450046

出　　处：《中国实验方剂学杂志》2024年第24期208-214,共7页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金项目(81973904,82305309);河南省特色学科中医学学科建设项目(STG-ZYXKY-2020023);河南省特色骨干学科中医学项目(STG-ZYX06-202144);2023年度河南省中医学“双一流”创建科学研究专项(HSRP-FCTCM-2023-3-06,HSRP-DFCTCM-2023-2-08)。

摘　　要：葶苈大枣泻肺汤是历代治疗肺痈、支饮的经典名方,收录于《古代经典名方目录(第二批)》。该文采用文献计量法对葶苈大枣泻肺汤的源流、出处、关键信息进行了考证和分析,为其名方产品开发与应用提供理论依据。结果发现,葶苈大枣泻肺汤首见于《金匮要略》,原书录有3条临床应用,明确表示该方治疗肺痈及支饮病证,喘不得卧、胸胁胀满、面目浮肿、支饮不得息、咳逆,与古代应用考证结果相符,后世用药与组方大多沿用仲景之法。葶苈大枣泻肺汤现代用法集中于呼吸系统,以胸腔积水为多见。其用药及煎服法笔者建议单次用量为独行菜Lepidium apetalum的干燥成熟种子葶苈子5 g,炮制规格为炒葶苈子,鼠李科植物枣Ziziphus jujuba的干燥成熟果实大枣用36 g,炮制规格为生品,加水600 mL,先煮大枣至400 mL,过滤枣渣取上清液。后加入炒葶苈子,煮取200 mL,一次服尽。上述研究为其名方产品开发与应用提供了理论依据。Tingli Dazao Xiefeitang is a classic formula for treating lung abscesses and thoracic fluid retention,recognized throughout history and included in the Catalogue of Ancient Classic Formulas(Second Batch).This article employs bibliometric methods to investigate and analyze the source,origin,and key information of Tingli Dazao Xiefeitang,providing a theoretical basis for the development and application of this renowned formula.The results show that Tingli Dazao Xiefeitang first appears in Synopsis of the Golden Chamber(Jin Kui Yao Lue),where three clinical applications are recorded.The original text clearly states that this formula is used to treat lung abscesses and thoracic fluid retention,with symptoms such as inability to lie down due to wheezing,chest and rib fullness,facial edema,inability to rest due to thoracic fluid retention,and cough inversion.This aligns with findings from ancient application research.In later generations,the methods proposed by ZHANG Zhongjing were predominantly used for medication and formulation.Modern applications of Tingli Dazao Xiefeitang focus primarily on the respiratory system,with pleural effusion being the most common condition.For the preparation and decoction,a single dose of 5 g of Descurainiae Semen Lepidii Semen(dried and mature seeds of Lepidium apetalum)processed as stir-fried seeds and 36 g of Jujubae Fructus(dried and mature fruit of Ziziphus jujuba)prepared as raw materials were recommended.Then 600 mL of water was added and Jujubae Fructus was first boiled until the volume reduced to 400 mL.After filtering out the residue,the supernatant was retained and mixed with stir-fried Descurainiae Semen Lepidii Semen,followed by boiling to 200 mL,which should be consumed all at once.This research provides a theoretical basis for the development and application of this formula.

关 键 词：葶苈大枣泻肺汤 经典名方 考证 古今应用 关键信息 

分 类 号：R284[医药卫生—中药学] R285[医药卫生—中医学] R289R287R22R2-031R33R24