基于临床实践指南构建中医智能化诊疗本体--以冠心病为例  

Construction of an Intelligent Diagnosis and Treatment Ontology for Traditional Chinese Medicine Based on Clinical Practice Guidelines:A Case Study of Coronary Heart Disease

作　　者：宋晓慧 张华敏[1] 郭壮 尹继瑶 刘孟涵 张娟 牛琪锴 王俊文 SONG Xiaohui;ZHANG Huamin;GUO Zhuang;YIN Jiyao;LIU Menghan;ZHANG Juan;NIU Qikai;WANG Junwen(Institute of Basic Theory for Chinese Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China;Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China)

机构地区：[1]中国中医科学院中医基础理论研究所,北京100700 [2]中国中医科学院中药研究所,北京100700

出　　处：《中国实验方剂学杂志》2024年第24期243-249,共7页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家重点研发计划项目(2023YFC3502900);中国中医科学院科技创新工程重大攻关项目(CI2021A00113);中国中医科学院基本科研业务费优秀青年科技人才(传承类)培养专项(ZZ13-YQ-110);国家自然科学基金面上项目(82074334);中央级公益性科研院所基本科研业务费专项(YZX-202321)。

摘　　要：目的:运用本体和知识图谱构建技术,实现临床实践指南的信息化,为智能中医临床辅助决策提供支持。方法:基于可发现(Findability)、可获取(Accessibility)、可互操作(Interoperability)和可复用(Reusability)原则(FAIR原则),运用本体技术构建中医临床实践指南本体,并以冠心病为例构建知识图谱。以《中医临床实践指南报告清单》和《中医药临床指南/共识中推荐意见分级(T/CAS 530—2021)》为依据,采用七步本体构建法构建中医临床实践指南本体,在此基础上,通过知识抽取、知识融合和知识存储,将《冠心病稳定型心绞痛中医诊疗指南》中的中医诊疗数据以三元组的形式存储于Neo4j中。结果:将临床实践指南中的信息分为发病及预防信息、诊断信息和治疗信息三大类,构建了中医临床实践指南本体,共获得了27个中医临床诊疗相关概念及14种数据属性,并建立了包含层级关系和对象属性在内的12种概念关系。以冠心病为例,将中医临床实践指南本体作为模式层,构建了包含276个节点和336个关系的冠心病稳定型心绞痛中医诊疗指南知识图谱,实现了指南内容的可视化展示和查询。结论:结合七步本体构建法和Neo4j图数据库技术构建的中医临床实践指南本体和冠心病稳定型心绞痛知识图谱具有高效性和灵活性,提供了一种智能中医诊疗方案,推动了中医诊疗的规范化和客观化。Objective:To support intelligent clinical decision-making in traditional Chinese medicine(TCM),this study utilized ontology and knowledge graph construction techniques to achieve the IT application of clinical practice guidelines.Method:Based on the principles of findability,accessibility,interoperability,and reusability(FAIR principles),this study employed ontology techniques to construct an ontology for TCM clinical practice guidelines and built a knowledge graph using coronary heart disease as an example.Based on the Checklist for Reporting Practice Guidelines in Traditional Chinese Medicine and Recommendation Grading in TCM Clinical Guidelines/Consensus(T/CAS 530—2021),the ontology of TCM clinical practice guidelines was constructed using the seven-step ontology construction method.On this basis,the TCM diagnosis and treatment data from the Guidelines for the Diagnosis and Treatment of Stable Angina Pectoris in Coronary Heart Disease were stored in Neo4j in the form of triples through knowledge extraction,integration,and storage.Result:The information in the clinical practice guidelines was divided into three categories:onset and prevention information,diagnosis information,and treatment information,and the TCM clinical practice guideline ontology was constructed.A total of 27 concepts related to TCM clinical diagnosis and treatment and 14 data attributes were obtained,and 12 conceptual relationships including hierarchical relationships and object attributes were established.By taking coronary heart disease as an example and the TCM clinical practice guideline ontology as the model layer,the knowledge map of TCM diagnosis and treatment guidelines for stable angina pectoris in coronary heart disease with 276 nodes and 336 relationships was constructed,realizing the visual display and query of the guideline content.Conclusion:The ontology of TCM clinical practice guidelines and the knowledge graph of stable angina pectoris in coronary heart disease constructed by combining the sevenstep ontology construction

关 键 词：本体 中医临床实践指南 知识图谱 冠心病 

分 类 号：R2-031[医药卫生—中西医结合] R932[医药卫生—中医学] R256.35R442.2R288R541.4R256.2